Clinical outcome and molecular characterization of brain metastases from esophageal and gastric cancer: a systematic review

被引：26

作者：

Ghidini, Michele ^{[1
]}

Petrelli, Fausto ^{[2
]}

Hahne, Jens Claus ^{[3
]}

De Giorgi, Annamaria ^{[4
]}

Toppo, Laura ^{[1
]}

Pizzo, Claudio ^{[1
]}

Ratti, Margherita ^{[1
]}

Barni, Sandro ^{[2
]}

Passalacqua, Rodolfo ^{[1
]}

Tomasello, Gianluca ^{[1
]}

机构：

[1] Osped Cremona, ASST Cremona, Dept Oncol, Oncol Unit, Viale Concordia 1, I-26100 Cremona, Italy

[2] Osped Treviglio, ASST Bergamo Ovest, Dept Oncol, Oncol Unit, Piazzale Osped 1, I-24047 Treviglio, BG, Italy

[3] Inst Canc Res, Div Mol Pathol, Lab Gastrointestinal Canc Biol & Genom, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England

[4] Osped Circolo & Fdn Macchi, ASST Sette Laghi, Dept Oncol, Oncol Unit, Viale Luigi Borri 57, I-21100 Varese, Italy

来源：

MEDICAL ONCOLOGY | 2017年 / 34卷 / 04期

关键词：

Brain metastases; Gastric cancer; Esophageal cancer; Stereotactic radiosurgery; Radiotherapy; CENTRAL-NERVOUS-SYSTEM; GAMMA-KNIFE RADIOSURGERY; OF-THE-LITERATURE; PROGNOSTIC-FACTORS; LEPTOMENINGEAL CARCINOMATOSIS; STEREOTACTIC RADIOSURGERY; RADIATION-THERAPY; GASTROESOPHAGEAL ADENOCARCINOMA; GASTROINTESTINAL-TRACT; RETROSPECTIVE ANALYSIS;

D O I：

10.1007/s12032-017-0919-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of the study was to collect the available data on central nervous system (CNS) metastases from esophageal and gastric cancer. A PubMed, EMBASE, SCOPUS, Web of Science, LILACS, Ovid and Cochrane Library search was performed. Thirty-seven studies including 779 patients were considered. Among the data extracted, treatment of tumor and brain metastases (BMs), time to BMs development, number and subsite, extracerebral metastases rate, median overall survival (OS) and prognostic factors were included. For esophageal cancer, the median OS from diagnosis of BMs was 4.2 months. Prognostic factors for OS included: performance status, multimodal therapy, adjuvant chemotherapy, single BM, brain only disease and surgery. For gastric cancer, median OS was 2.4 months. Prognostic factors for OS included: recursive partitioning analysis class 2, stereotactic radiosurgery (SRT) and use of intrathecal therapy. HER2-positive gastric cancer was shown to be associated with a higher risk and shorter time to CNS relapse. Patients harboring BMs from gastric and esophageal tumors, except cases with single lesions that are treated aggressively, have a poor prognosis. SRT (plus or minus surgery and whole brain radiotherapy) seems to give better results in terms of longer OS after brain relapse.

引用

页数：10

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