Preparation and Drug Delivery Properties of Mg-Doped Hydroxyapatite Nanoparticles

被引：5

作者：

Ma Xiao-Yu ^{[1
]}

Liu Yong-Jia ^{[1
]}

Zhu Bang-Shang ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, Instrumental Anal Ctr, Shanghai 200240, Peoples R China

来源：

CHINESE JOURNAL OF INORGANIC CHEMISTRY | 2018年 / 34卷 / 05期

关键词：

magnesium doped hydroxyapatite; step reaction; cisplatin; drug loading; MAGNESIUM-SUBSTITUTED HYDROXYAPATITE; CALCIUM PHOSPHATES; SYSTEM; CRYSTALLIZATION; IONS; PH;

D O I：

10.11862/CJIC.2018.106

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Magnesium-doped hydroxyapatites nanoparticles (Mg-HAs) with different feeding molar ratios were synthesized by step precipitation reaction and one pot reaction. The morphology and size of the Mg-HAs were controlled by different feeding molar ratio of magnesium nitrate and calcium nitrate. The Mg-HAs were characterized by transmission electron microscope, X-ray diffraction, et al. MTT method was used to evaluated in vitro cytotoxicity of the Mg-HAs. Results show that the synthesized Mg-HAs had the frame with fiber like structure, high specific surface area and low cell cytotoxicity. Mg-HAs as drug carrier material and cisplatin (cDDP) as a model drug were investigated, and the max loading rate was 54.84%. The drug loading Mg-HAs also have release properties (the releasing rate is 41.72% after 72 h), and a better inhibitory effect on cancer cells.

引用

页码：917 / 924

页数：8

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