Molecular mechanisms of maculopapular exanthema

被引：37

作者：

Fernandez, Tahia D. ^{[1
]}

Canto, Gabriela ^{[2
]}

Blanca, Miguel ^{[3
]}

机构：

[1] Carlos Haya Hosp, Fdn IMABIS, Allerg Dis Res Lab, Malaga, Spain

[2] Infanta Leonor Hosp, Allergy Serv, Madrid, Spain

[3] Carlos Haya Hosp, Allergy Serv, Malaga, Spain

来源：

CURRENT OPINION IN INFECTIOUS DISEASES | 2009年 / 22卷 / 03期

关键词：

chemokines; cytokines; oxidative stress; skin; T-lymphocytes; ALLERGIC REACTIONS; T-CELLS; HYPERSENSITIVITY REACTIONS; NONIMMEDIATE REACTIONS; CUTANEOUS REACTIONS; ATOPIC-DERMATITIS; DRUG-REACTIONS; YOUNG-ADULTS; CYTOKINE; SKIN;

D O I：

10.1097/QCO.0b013e3283298e62

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Purpose of review Maculopapular exanthema is a common cutaneous manifestation of many diseases produced by several agents able to activate the immune system, the most common of which are drugs and viruses. In spite of its high frequency, knowledge of the molecular mechanisms involved remains scarce. Recent findings The cytokine patterns in maculopapular exanthema have a Th1 or Th0 pattern, according to whether the reaction is induced by a drug or a virus, respectively. Additionally, the involvement of CD4 T-lymphocytes with cytotoxic capabilities has been shown in the former. Different chemokines and their receptors are also involved in skin homing, such as CCL20, CCL27, CXCL9 or CXCL10, and oxidative stress can help exacerbate the symptoms. Summary These findings may be very important for the diagnostic evaluation of these entities and for the development of new tools for diagnosis and treatment.

引用

页码：272 / 278

页数：7

共 53 条

[1]

ADKINSON NF, 2003, MIDDLETONS ALLERGY P, V2, P1679

[2] Carbamazepine-induced hypersensitivity syndrome associated with transient hypogammaglobulinaemia and reactivation of human herpesvirus 6 infection demonstrated by real-time quantitative polymerase chain reaction [J].

Aihara, Y ;

Ito, SI ;

Kobayashi, Y ;

Yamakawa, Y ;

Aihara, M ;

Yokota, S .

BRITISH JOURNAL OF DERMATOLOGY, 2003, 149 (01) :165-169

[3] Different cytokine production and activation marker profiles in circulating cutaneous-lymphocyte-associated antigen+ T cells from patients with acute or chronic atopic dermatitis [J].

Antúnez, C ;

Torres, MJ ;

Mayorga, C ;

Cornejo-García, JA ;

Santamaría-Babi, LF ;

Blanca, M .

CLINICAL AND EXPERIMENTAL ALLERGY, 2004, 34 (04) :559-566

[4] Immunocompetent cells and adhesion molecules in 14 cases of cutaneous drug reactions induced with the use of antibiotics [J].

Barbaud, AM ;

Béné, MC ;

Reichert-Penetrat, S ;

Jacquin-Petit, MA ;

Schmutz, JL ;

Faure, GC .

ARCHIVES OF DERMATOLOGY, 1998, 134 (08) :1040-1041

[5]

Bigby M, 2001, ARCH DERMATOL, V137, P765

[6]

BLANCA M, 1995, ALLERGY, V50, P777

[7] Antioxidant activity, lipid peroxidation and skin diseases. What's new [J].

Briganti, S ;

Picardo, M .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2003, 17 (06) :663-669

[8]

Brugnolo F, 1999, J IMMUNOL, V163, P1053

[9] The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells [J].

Campbell, JJ ;

Haraldsen, G ;

Pan, J ;

Rottman, J ;

Qin, S ;

Ponath, P ;

Andrew, DP ;

Warnke, R ;

Ruffing, N ;

Kassam, N ;

Wu, L ;

Butcher, EC .

NATURE, 1999, 400 (6746) :776-780

[10] Differential cytokine and transcription factor expression in patients with allergic reactions to drugs [J].

Cornejo-Garcia, J. A. ;

Fernandez, T. D. ;

Torres, M. J. ;

Carballo, M. ;

Hernan, I. ;

Antunez, C. ;

Blanca, M. ;

Mayorga, C. .

ALLERGY, 2007, 62 (12) :1429-1438

← 1 2 3 4 5 6 →