Label-free detection of pH based on the i-motif using an aggregation-caused quenching strategy

被引：43

作者：

Fu, Boshi ^{[1
]}

Huang, Jinguo ^{[1
]}

Bai, Dongsheng ^{[1
]}

Xie, Yalun ^{[1
]}

Wang, Yang ^{[1
]}

Wang, Shaoru ^{[1
]}

Zhou, Xiang ^{[1
]}

机构：

[1] Coll Chem & Mol Sci, Key Lab Biomed Polymers, Minist Educ, Inst Adv Studies, Wuhan 68756663, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 95期

关键词：

MOLECULAR DEVICES; DNA; TELOMERE; CANCER; DESIGN;

D O I：

10.1039/c5cc04784f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A label-free and biocompatible pH sensor system based on the aggregation-caused quenching (ACQ) probe has been reported herein. The DNA i-motif, a kind of pH-triggered structure, affects the aggregation of PTCDI derivatives by structural switch that would provide significant fluorescence signals responding to the different pH values. Our method not only shows sensitive and reversible response to pH changes, but also could expand the detection range by allosteric control of the DNA i-motif.

引用

页码：16960 / 16963

页数：4

共 19 条

[1] Regulation of the Na+/H+ Exchanger (NHE1) in Breast Cancer Metastasis [J].

Amith, Schammim R. ;

Fliegel, Larry .

CANCER RESEARCH, 2013, 73 (04) :1259-1264

[2] DNA-based machines [J].

Beissenhirtz, Moritz K. ;

Willner, Itamar .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2006, 4 (18) :3392-3401

[3] The i-motif in nucleic acids [J].

Guéron, M ;

Leroy, JL .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2000, 10 (03) :326-331

[4] Nucleic Acid Based Molecular Devices [J].

Krishnan, Yamuna ;

Simmel, Friedrich C. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (14) :3124-3156

[5] Probing structural changes of self assembled i-motif DNA [J].

Lee, Il Joon ;

Patil, Sachin P. ;

Fhayli, Karim ;

Alsaiari, Shahad ;

Khashab, Niveen M. .

CHEMICAL COMMUNICATIONS, 2015, 51 (18) :3747-3749

[6]

Leroy L. J., 1994, NUCLEIC ACIDS RES, V22, P1600

[7] Folding versus self-assembling [J].

Li, ADQ ;

Wang, W ;

Wang, LQ .

CHEMISTRY-A EUROPEAN JOURNAL, 2003, 9 (19) :4594-4601

[8] REGULATION OF INTRACELLULAR PH IN EUKARYOTIC CELLS [J].

MADSHUS, IH .

BIOCHEMICAL JOURNAL, 1988, 250 (01) :1-8

[9] Water Soluble Cationic Perylene Derivatives as Possible Telomerase Inhibitors: The Search for Selective G-Quadruplex Targeting [J].

Micheli, Emanuela ;

D'Ambrosio, Danilo ;

Franceschin, Marco ;

Savino, Maria .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2009, 9 (14) :1622-1632

[10] DNA logic gates based on structural polymorphism of telomere DNA molecules responding to chemical input signals [J].

Miyoshi, Daisuke ;

Inoue, Mamiko ;

Sugimoto, Naoki .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (46) :7716-7719

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