Internalization of cationic peptides: the road less (or more?) traveled

被引：82
作者：
Fuchs, S. M.
Raines, R. T.
机构：
[1] Univ Wisconsin, Dept Biochem, Madison, WI 53705 USA
[2] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2006年 / 63卷 / 16期
关键词：
endocytosis; heparan sulfate proteoglycan; HIV-TAT; polyarginine; protein transduction domain;
D O I：
10.1007/s00018-006-6170-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Facilitating the entry of molecules into mammalian cells is of great interest to fields as diverse as cell biology and drug delivery. The discovery of natural protein transduction domains and the development of artificial ones, including polyarginine, provides a means to achieve this goal. Here, we comment on key chemical and biological aspects of cationic peptide internalization, including the physiological relevance of this process.
引用
收藏
页码：1819 / 1822
页数：4
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