Processing of Listeria monocytogenes antigens and the in vivo T-cell response to bacterial infection

被引:41
作者
Busch, DH
Kerksiek, K
Pamer, EG
机构
[1] Yale Univ, Sch Med, Infect Dis Sect, New Haven, CT 06520 USA
[2] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA
关键词
D O I
10.1111/j.1600-065X.1999.tb01364.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Presentation of antigens to T lymphocytes is a critical step in the clearance of pathogens from their hosts and in the establishment of protective immunity. Several animal models have been developed to study this process, but few have been as informative as the murine immune response to Listeria monocytogenes infection. Herein we review the presentation of L. monocytogenes proteins by the MHC class I antigen-processing pathway and the in vivo T-cell response to these bacterial antigens. These studies demonstrate the following: 1) The size of a peptide-specific T-cell response does not correlate with the amount of epitope presented by infected cells; 2) T cells specific for dominant epitopes do not, in the case of L. monocytogenes infection, inhibit responses to subdominant epitopes; 3) T cells responding to different epitopes presented by MHC class Ia molecules expand, contract and enter the memory pool synchronously; 4) Repeated in vivo expansion of antigen-specific T-cell populations results in a narrowing of their T-cell receptor repertoire and in an increase in their affinity for antigen; and 5) T cells restricted by H2-M3 MHC class Ib molecules constitute a major parr of the primary response to bacterial infection, but appear to play a relatively smaller role in memory responses. These studies have provided a novel glimpse of the relationship between antigen processing and in vivo T-cell responses to infection, and provide a foundation for more detailed analyses of T-cell-mediated adaptive immunity.
引用
收藏
页码:163 / 169
页数:7
相关论文
共 59 条
[1]   Supraoptimal peptide major histocompatibility complex causes a decrease in Bcl-2 levels and allows tumor necrosis factor α receptor II-mediated apoptosis of cytotoxic T lymphocytes [J].
Alexander-Miller, MA ;
Derby, MA ;
Sarin, A ;
Henkart, PA ;
Berzofsky, JA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (08) :1391-1399
[2]   Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy [J].
AlexanderMiller, MA ;
Leggatt, GR ;
Berzofsky, JA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (09) :4102-4107
[3]  
BERCHE P, 1987, J IMMUNOL, V138, P2266
[4]  
BISHOP DK, 1987, J IMMUNOL, V139, P2005
[5]   Existing antilisterial immunity does not inhibit the development of a Listeria monocytogenes-specific primary cytotoxic T-lymphocyte response [J].
Bouwer, HGA ;
Shen, H ;
Fan, X ;
Miller, JF ;
Barry, RA ;
Hinrichs, DJ .
INFECTION AND IMMUNITY, 1999, 67 (01) :253-258
[6]  
Bruder D, 1998, EUR J IMMUNOL, V28, P2630, DOI 10.1002/(SICI)1521-4141(199809)28:09<2630::AID-IMMU2630>3.0.CO
[7]  
2-Z
[8]   EXPRESSION AND PHOSPHORYLATION OF THE LISTERIA-MONOCYTOGENES ACTA PROTEIN IN MAMMALIAN-CELLS [J].
BRUNDAGE, RA ;
SMITH, GA ;
CAMILLI, A ;
THERIOT, JA ;
PORTNOY, DA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) :11890-11894
[9]  
BRUNT LM, 1990, J IMMUNOL, V145, P3540
[10]   STRUCTURAL AND FUNCTIONAL-PROPERTIES OF THE P60 PROTEINS FROM DIFFERENT LISTERIA SPECIES [J].
BUBERT, A ;
KUHN, M ;
GOEBEL, W ;
KOHLER, S .
JOURNAL OF BACTERIOLOGY, 1992, 174 (24) :8166-8171