Neutralizing antibody rather than cellular immune response is maintained for nearly 20 years among Japanese encephalitis SA14-14-2 vaccinees in an endemic setting

被引：5
作者：
Wang, Ran [1 ,2 ]
Fan, Dongying [2 ]
Wang, Lei [3 ]
Li, Yueqi [2 ]
Zhou, Hongning [4 ]
Gao, Na [2 ]
An, Jing [2 ,5 ]
机构：
[1] Capital Med Univ, Natl Ctr Childrens Hlth,Minist Educ,Beijing Key L, Beijing Pediat Res Inst,Lab Infect & Virol,Natl C, Res Unit Crit Infect Children,Chinese Acad Med Sc, Beijing 100045, Peoples R China
[2] Capital Med Univ, Sch Basic Med Sci, Dept Microbiol & Parasitol, Beijing 100069, Peoples R China
[3] Cangzhou Med Coll, Fac Pathogen Biol & Immunol, Dept Basic Med Sci, Cangzhou 061001, Hebei, Peoples R China
[4] Yunnan Inst Parasit Dis, Yunnan Prov Key Lab Vector Borne Dis Control & Re, Simao 665000, Yunnan, Peoples R China
[5] Beijing Inst Brain Disorders, Ctr Epilepsy, Beijing 100069, Peoples R China
来源：
INFECTION GENETICS AND EVOLUTION | 2020年 / 85卷
基金：
中国国家自然科学基金;
关键词：
Japanese encephalitis virus; SA14-14-2; Seroprevalence; IgG; Neutralization antibody; IFN-gamma; PROTECTION; OUTBREAK; VIRUS; CHINA; SEX;
D O I：
10.1016/j.meegid.2020.104476
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Japanese encephalitis (JE), caused by infection with Japanese encephalitis virus (JEV), is the most important viral encephalitis in Asia. JE incidence has significantly decreased by immunization with live-attenuated vaccine SA14-14-2. However, the duration of immune response overtime after vaccination is inconclusive and may be associated with the risk of JE occurrence in adults. A cross-sectional study was conducted in 961 JE-vaccinated local residents aged 19-20 years in Beijing, China. 620 (65%) and 513 (53%) individuals were anti-JEV IgG antibody and neutralizing antibody (nAb) positive, respectively. The geometric mean titer (GMT) of nAb was 1:11, suggesting a seroprotection among the study population. As for IFN-gamma production, peripheral blood mononuclear cell (PBMC) samples isolated from 60 subjects showed negative response following the stimulation with concentrated JEV particles. Overall, longer persistence of nAb response among vaccinees is observed than that of cellular immune response after 17-18 years of vaccination. Taken together, our results not only provide the data for evaluating herd immunity against JEV among vaccinated adults in Beijing but also offer useful information for JE prevention and control in endemic areas.
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页数：4
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