Wnt signal transduction: kinase cogs in a nano-machine?

被引：40

作者：

Ding, YN ^{[1
]}

Dale, T ^{[1
]}

机构：

[1] Inst Canc Res, Dev Biol Team, Sect Cell & Mol Biol, London SW3 6JB, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 07期

关键词：

D O I：

10.1016/S0968-0004(02)02137-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The control of beta-catenin levels is vital to the cell. The primary means of regulation is through ubiquitin-mediated degradation. This process is regulated by Wnt signalling and is frequently disrupted in cancer. Three recent papers show that the initial step in marking beta-catenin for degradation involves phosphorylation by casein kinase 1. This then allows phosphorylation by glycogen synthase kinase-3, and the recruitment of ubiquitin-ligase components.

引用

页码：327 / 329

页数：3

共 19 条

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