Cathepsin L targeting in cancer treatment

被引：131
作者：
Sudhan, Dhivya R. [1 ]
Siemann, Dietmar W. [1 ,2 ]
机构：
[1] Univ Florida, Hlth Canc Ctr, Dept Radiat Oncol, Gainesville, FL 32610 USA
[2] Univ Florida, Coll Med, Dept Pharmacol & Therapeut, Gainesville, FL 32610 USA
来源：
PHARMACOLOGY & THERAPEUTICS | 2015年 / 155卷
关键词：
Cathepsin L; Metastasis; Bone resorption; Cancer; Protease targeting; MAJOR EXCRETED PROTEIN; MATRIX-METALLOPROTEINASE INHIBITORS; PROCATHEPSIN-L SECRETION; STRUCTURE-BASED DESIGN; HIGH LACTATE LEVELS; CLEAVES HUMAN C3; BREAST-CANCER; CYSTEINE PROTEINASES; BONE METASTASES; L EXPRESSION;
D O I：
10.1016/j.pharmthera.2015.08.007
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Proteolytic enzymes may serve as promising targets for novel therapeutic treatment strategies seeking to impede cancer progression and metastasis. One such enzyme is cathepsin L (CTSL), a lysosomal cysteine protease. CTSL upregulation, a common occurrence in a variety of human cancers, has been widely correlated with metastatic aggressiveness and poor patient prognosis. In addition, CTSL has been implicated to contribute to cancer-associated osteolysis, a debilitating morbidity affecting both life expectancy and the quality of life. In this review, we highlight the mechanisms by which CTSL contributes to tumor progression and dissemination and discuss the therapeutic utility of CTSL intervention strategies aimed at impeding metastatic progression and bone resorption. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：105 / 116
页数：12
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