Organogenic role of B lymphocytes in mucosal immunity

被引：191

作者：

Golovkina, TV

Shlomchik, M

Hannum, L

Chervonsky, A

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

[2] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06510 USA

[3] Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06510 USA

来源：

SCIENCE | 1999年 / 286卷 / 5446期

关键词：

D O I：

10.1126/science.286.5446.1965

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Follicle-associated epithelium (FAE) in the intestinal Peyer's patches contains M cells that deliver pathogens to organized Lymphoid tissue. Development of Peyer's patches, FAE, and M cells was found to be impaired in mice that had no B cells. Transgenic expression of membrane-bound immunoglobulin M restored B cells and FAE development. The Lack of M cells abrogated infection with a milk-borne retrovirus. Thus, in addition to secretion of antibodies and presentation of antigens, B cells are important for organogenesis of the mucosal immune barriers.

引用

页码：1965 / 1968

页数：4

共 45 条

[1]

ACHAORBEA H, 1995, ANNU REV IMMUNOL, V13, P459, DOI 10.1146/annurev.immunol.13.1.459

[2] Three distinctive steps in Peyer's patch formation of murine embryo [J].