Collagen VI protects neurons against Aβ toxicity

被引：107

作者：

Cheng, Jason S. ^{[1
]}

Dubal, Dena B. ^{[1
,2
]}

Kim, Daniel H. ^{[1
]}

Legleiter, Justin ^{[1
,2
]}

Cheng, Irene H. ^{[1
,2
]}

Yu, Gui-Qiu ^{[1
]}

Tesseur, Ina ^{[3
]}

Wyss-Coray, Tony ^{[3
]}

Bonaldo, Paolo ^{[4
]}

Mucke, Lennart ^{[1
,2
]}

机构：

[1] Gladstone Inst Neurol Dis, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA

[3] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[4] Univ Padua, I-35100 Padua, Italy

来源：

NATURE NEUROSCIENCE | 2009年 / 12卷 / 02期

基金：

美国国家卫生研究院;

关键词：

AMYLOID PRECURSOR PROTEIN; MOUSE; DEFICIENCY; EXPRESSION; MICE;

D O I：

10.1038/nn.2240

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Amyloid-beta (A beta) peptides, widely presumed to cause Alzheimer's disease, increased mouse neuronal expression of collagen VI through a mechanism involving transforming growth factor signaling. Reduction of collagen VI augmented A beta neurotoxicity, whereas treatment of neurons with soluble collagen VI blocked the association of A beta oligomers with neurons, enhanced A beta aggregation and prevented neurotoxicity. These results identify collagen VI as an important component of the neuronal injury response and demonstrate its neuroprotective potential.

引用

页码：119 / 121

页数：3

共 50 条

[21] The antidepressant phenelzine protects neurons and astrocytes against formaldehyde-induced toxicity
Song, Mee-Sook
Baker, Glen B.
Dursun, Serdar M.
Todd, Kathryn G.
JOURNAL OF NEUROCHEMISTRY, 2010, 114 (05) : 1405 - 1413
[22] Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity
Kihara, T
Shimohama, S
Sawada, H
Kimura, J
Kume, T
Kochiyama, H
Maeda, T
Akaike, A
ANNALS OF NEUROLOGY, 1997, 42 (02) : 159 - 163
[23] Glucocorticoids reduce intracellular calcium concentration and protects neurons against glutamate toxicity
Suwanjang, Wilasinee
Holmstroem, Kira M.
Chetsawang, Banthit
Abramov, Andrey Y.
CELL CALCIUM, 2013, 53 (04) : 256 - 263
[24] Pyruvate protects motor neurons expressing mutant superoxide dismutase I against copper toxicity
Kim, HJ
Kim, JM
Park, JH
Sung, JJ
Kim, M
Lee, KW
NEUROREPORT, 2005, 16 (06) : 585 - 589
[25] Idebenone protects mitochondrial function against amyloid beta toxicity in primary cultured cortical neurons
Wang, Huiting
Li, Lei
Jia, Kun
Wang, Qi
Sui, Shaomei
Lin, Yicheng
He, Yan
NEUROREPORT, 2020, 31 (15) : 1104 - 1110
[26] Overexpression of PHGPX (GPX4) protects neurons against oxidative insults and amyloid toxicity
Ran, O
VanRemmen, H
Gu, M
Richardson, A
GERONTOLOGIST, 2004, 44 : 21 - 21
[27] MK-801 SELECTIVELY PROTECTS MOUSE ARCUATE NEURONS INVIVO AGAINST GLUTAMATE TOXICITY
LEHMANN, A
JONSSON, T
NEUROREPORT, 1992, 3 (05) : 421 - 424
[28] Thyroid Hormone Increases Astrocytic Glutamate Uptake and Protects Astrocytes and Neurons Against Glutamate Toxicity
Nedel Mendes-de-Aguiar, Claudia Beatriz
Alchini, Ricardo
Decker, Helena
Alvarez-Silva, Marcio
Tasca, Carla Ines
Trentin, Andrea Goncalves
JOURNAL OF NEUROSCIENCE RESEARCH, 2008, 86 (14) : 3117 - 3125
[29] Activation of cannabinoid receptor 2 protects rat hippocampal neurons against Aβ-induced neuronal toxicity
Zhao, Jingfu
Wang, Mengzhen
Liu, Wei
Ma, Zegang
Wu, Jie
NEUROSCIENCE LETTERS, 2020, 735
[30] CIMETIDINE PROTECTS AGAINST ACETAMINOPHEN TOXICITY
JACKSON, JE
VETERINARY AND HUMAN TOXICOLOGY, 1981, 23 (05) : 351 - 351

← 1 2 3 4 5 →