DIPEPTIDYL PEPTIDASE IV (CD26) ACTIVITY IN DIFFERENT LYMPHOCYTE POPULATIONS OF HUMAN PERIPHERAL BLOOD AFTER MITOGEN STIMULATION

被引：0

作者：

Dimitrova, Mashenka ^{[1
]}

Ivanov, Ivaylo ^{[2
]}

Georgieva, Lillia ^{[1
]}

Nikolova, Elena ^{[1
]}

机构：

[1] Bulgarian Acad Sci, Inst Expt Morphol & Anthropol, BU-1113 Sofia, Bulgaria

[2] St Kl Ohridski Sofia Univ, Fac Biol, Sofia, Bulgaria

来源：

COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES | 2009年 / 62卷 / 05期

关键词：

dipeptidyl peptidase IV; lymphocyte; PHA; ConA; LPS; ENZYMATIC-ACTIVITY; ANTIGEN;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A novel procedure for the simultaneous visualization of cell differentiation antigens (CD) by immunocytochemistry and CD26/ Dipeptidyl peptidase IV (DPP IV) activity by fluorescent enzyme cytochemistry was developed. This procedure was used for the determination of the percentage of DPP IV-positive cells from different subpopulations of human peripheral blood lymphocytes at rest and after mitogen stimulation. The number of DPP IV+ T and B cells increased after application of mitogenic stimuli. These results might help for elucidation of the role of CD26 proteolytic activity in the exertion of its costimulatory effect upon the immune response.

引用

页码：603 / 608

页数：8

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