Detection and manipulation of biomolecules by magnetic carriers

被引：72
作者：
Brzeska, M
Panhorst, M
Kamp, PB
Schotter, J
Reiss, G
Pühler, A
Becker, A
Brückl, H
机构：
[1] Univ Bielefeld, Dept Phys, D-33615 Bielefeld, Germany
[2] Univ Bielefeld, Dept Genet, D-33615 Bielefeld, Germany
来源：
JOURNAL OF BIOTECHNOLOGY | 2004年 / 112卷 / 1-2期
关键词：
molecular recognition; biochip; marker; sensor; magnetoresistive; bonding force;
D O I：
10.1016/j.jbiotec.2004.04.018
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The detection and manipulation of single molecules on a common platform would be of great interest for basic research of biological or chemical systems. A promising approach is the application of magnetic carriers. The principles are demonstrated in this contribution. It is shown that paramagnetic beads can be detected by highly sensitive magnetoresistive sensors yielding a purely electronic signal. Different configurations are discussed. The capability of the sensors to detect even single markers is demonstrated by a model experiment. In addition, the paramagnetic beads can be used as carriers for biomolecules. They can be manipulated on-chip via currents running through specially designed line patterns. Thus, magnetic markers in combination with magnetoresistive sensors are a promising choice for future integrated lab-on-a-chip systems. (C) 2004 Elsevier B.V. All rights reserved.
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收藏
页码：25 / 33
页数：9
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