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Cytoglobin as a Marker of Hepatic Stellate Cell-derived Myofibroblasts
被引:19
作者:
Kawada, Norifumi
[1
]
机构:
[1] Osaka City Univ, Grad Sch Med, Dept Hepatol, Osaka 558, Japan
来源:
FRONTIERS IN PHYSIOLOGY
|
2015年
/
6卷
基金:
日本学术振兴会;
关键词:
stellate cell;
cytoglobin;
myofibroblast;
liver fibrosis;
hypoxia;
LIVER FIBROSIS;
OVEREXPRESSION PROTECTS;
MESENCHYMAL TRANSITION;
PORTAL FIBROBLASTS;
TUMOR-SUPPRESSOR;
GENE-EXPRESSION;
FIBROTIC HUMAN;
NITRIC-OXIDE;
RAT-LIVER;
ACTIVATION;
D O I:
10.3389/fphys.2015.00329
中图分类号:
Q4 [生理学];
学科分类号:
071003 ;
摘要:
Myofibroblasts play important roles in inflammation, fibrosis and tumorigenesis in chronically inflamed liver. Liver myofibroblasts originate from hepatic stellate cells, portal fibroblasts or mesothelial cells, and they are localized in and around fibrotic septum and portal tracts. Liver myofibroblasts are the source of extracellular matrix materials, including type I collagen and multiple fibrogenic growth factors, such as transforming growth factor-beta and vascular endothelial growth factor. Although a detailed characterization of the function of individual myofibroblasts has not been conducted, owing to the lack of appropriate cell markers, recent lineage tracing technology has revealed the limited contribution of myofibroblasts that are derived from portal fibroblasts to various types of liver fibrosis, as compared with the contribution of hepatic stellate cells. In addition, cytoglobin, which is the fourth globin in mammals and function as a local gas sensor, provides a new perspective on the involvement of stellate cells in fibrosis and carcinogenesis, possibly through its anti-oxidative properties and is a promising new marker that discriminates between myofibroblasts derived from stellate cells and those from portal fibroblasts.
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