Atovaquone/Proguanil therapy for Plasmodium falciparum and Plasmodium vivax malaria in Indonesians who lack clinical immunity

被引：27

作者：

Lacy, MD

Maguire, JD

Barcus, MJ

Ling, J

Bangs, MJ

Gramzinski, R

Basri, H

Sismadi, P

Miller, GB

Chulay, JD

Fryauff, DJ

Hoffman, SL

Baird, JK

机构：

[1] USN, Parasit Dis Program, Med Res Unit 2, Jakarta, Indonesia

[2] Minist Hlth, Natl Inst Hlth Res & Dev, Jakarta, Indonesia

[3] George Washington Univ, Childrens Natl Med Ctr, Washington, DC USA

[4] GlaxoSmithKline, Res Triangle Pk, NC USA

[5] Naval Med Res Ctr, Malaria Program, Silver Spring, MD USA

来源：

CLINICAL INFECTIOUS DISEASES | 2002年 / 35卷 / 09期

关键词：

D O I：

10.1086/343750

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Thirty-eight of 295 subjects participating in a randomized, double-blind, placebo-controlled trial of the efficacy of daily administration of atovaquone/proguanil for malaria prevention developed malaria at some time during the 20-week prophylaxis period. These subjects (3 atovaquone/proguanil recipients and 35 placebo recipients) were treated with 4 tablets of atovaquone/proguanil per day for 3 days. Atovaquone/proguanil provided safe, well-tolerated, and effective therapy for uncomplicated malaria in nonimmune Indonesians.

引用

收藏

页码：E92 / E95

页数：4

相关论文

共 14 条

[1]

[Anonymous], 1973, WHO Tech. Rep. Ser

[2] TREATMENT OF CHLOROQUINE-RESISTANT PLASMODIUM-VIVAX WITH CHLOROQUINE AND PRIMAQUINE OR HALOFANTRINE [J].

BAIRD, JK ;

BASRI, H ;

SUBIANTO, B ;

FRYAUFF, DJ ;

MCELROY, PD ;

LEKSANA, B ;

RICHIE, TL ;

MASBAR, S ;

WIGNALL, FS ;

HOFFMAN, SL .

JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (06) :1678-1682

[3] Resurgent malaria at the millennium - Control strategies in crisis [J].

Baird, JK .

DRUGS, 2000, 59 (04) :719-743

[4] In vivo resistance to chloroquine by Plasmodium vivax and Plasmodium falciparum at Nabire, Irian Jaya, Indonesia [J].

Baird, JK ;

Wiady, I ;

Fryauff, DJ ;

Sutanihardja, MA ;

Leksana, B ;

Widjaya, H ;

Kysdarmanto ;

Subianto, B .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1997, 56 (06) :627-631

[5] Atovaquone-proguanil compared with chloroquine and chloroquine-sulfadoxine-pyrimethamine for treatment of acute Plasmodium falciparum malaria in the Philippines [J].

Bustos, DG ;

Canfield, CJ ;

Canete-Miguel, E ;

Hutchinson, DBA .

JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (06) :1587-1590

[6]

dos Santos CC, 1999, CAN MED ASSOC J, V160, P195

[7] Resurgent vector-borne diseases as a global health problem [J].

Gubler, DJ .

EMERGING INFECTIOUS DISEASES, 1998, 4 (03) :442-450

[8]

Kain KC, 1999, J TRAVEL MED, V6, pS2

[9] Randomized, placebo-controlled trial of Atovaquone/proguanil for the prevention of Plasmodium falciparum or Plasmodium vivax malaria among migrants to Papua, Indonesia [J].

Ling, J ;

Baird, JK ;

Fryauff, D ;

Sismadi, P ;

Bangs, MJ ;

Lacy, M ;

Barcus, MJ ;

Gramzinski, R ;

Maguire, JD ;

Kumusumangsih, M ;

Miller, GB ;

Jones, TR ;

Chulay, JD ;

Hoffman, SL .

CLINICAL INFECTIOUS DISEASES, 2002, 35 (07) :825-833

[10] Atovaquone and proguanil hydrochloride followed by primaquine for treatment of Plasmodium vivax malaria in Thailand [J].

Looareesuwan, S ;

Wilairatana, P ;

Glanarongran, R ;

Indravijit, KA ;

Supeeranontha, L ;

Chinnapha, S ;

Scott, TR ;

Chulay, JD .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1999, 93 (06) :637-640