Synthesis and anticonvulsant activity of some ω-(1H-1-imidazolyl)-N-phenylalkanoic acid amide derivatives

被引：17

作者：

Aktürk, Z

Kiliç, F

Erol, K

Pabuçcuoglu, V ^{[1
]}

机构：

[1] Ege Univ Bornova, Fac Pharm, Dept Pharmaceut Chem, TR-35100 Izmir, Turkey

[2] Osmangazi Univ, Fac Med, Dept Pharmacol, Eskisehir, Turkey

来源：

FARMACO | 2002年 / 57卷 / 03期

关键词：

anticonvulsant; MES; imidazole; anilide;

D O I：

10.1016/S0014-827X(01)01197-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study, 15 omega-(1H-imidazol-1-yl)-N-phenylacetamide, propionamide and butyramide derivatives having methoxyl, methyl, nitro and chloro in ortho position of N-phenyl ring or without any substituent have been realized by two-step synthesis. Their anticonvulsant activity was determined against seizures induced by maximal electroshock (MES). The most active compound in the series was 2-(1H-imidazol-1-yl)-N-(o-chlorophenyl)acetamide. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：201 / 206

页数：6

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