The interleukin 1-β exonic (+3953) polymorphism does not alter in vitro protein secretion

被引：20
作者：
Dominici, R
Malferrari, G
Mariani, C
Grimaldi, LME
Biunno, I
机构：
[1] Univ Milan, CNR, Inst Biomed Technol, I-20090 Segrate, Italy
[2] Univ Milan, CISI, I-20090 Segrate, Italy
[3] Osped L Sacco, Inst Biomed Sci, Milan, Italy
[4] Osped L Sacco, Dept Neurol, Milan, Italy
[5] DIBIT Milano, Dept Neurosci, I-93100 Caltanisetta, Italy
来源：
EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2002年 / 73卷 / 02期
关键词：
D O I：
10.1006/exmp.2002.2435
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Several studies have described polymorphisms in the genes encoding interleukin-1alpha (IL-1alpha) and IL-1beta cytokines and their implication in the onset of Alzheimer disease or in linkage disequilibrium with an as yet to be identified second locus on chromosome 2. However, these results have been associated with the sporadic forms of Alzheimer disease. Here we present data on the effects of the interleukin 1-beta exonic polymorphism (+3953) using a series of cohort healthy control samples and in vitro protein secretion assays. (C) 2002 Elsevier Science (USA).
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页码：139 / 141
页数：3
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