Circulating endocannabinoids and affect regulation in human subjects

被引：24

作者：

Coccaro, Emil F. ^{[1
]}

Hill, Matthew N. ^{[2
,3
]}

Robinson, Lauren ^{[1
]}

Lee, Royce J. ^{[1
]}

机构：

[1] Univ Chicago, Pritzker Sch Med, Dept Psychiat & Behav Neurosci, Clin Neurosci Res Unit, Chicago, IL 60637 USA

[2] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada

[3] Univ Calgary, Mathison Ctr Mental Hlth Res & Educ, Calgary, AB, Canada

来源：

PSYCHONEUROENDOCRINOLOGY | 2018年 / 92卷

基金：

加拿大健康研究院;

关键词：

Endocannabinoids; Depression; Anxiety; Affect regulation; POSTTRAUMATIC-STRESS-DISORDER; CANNABINOID MODULATION; RECEPTOR AVAILABILITY; CEREBROSPINAL-FLUID; SYSTEM; ANANDAMIDE; REDUCTIONS; INHIBITION; ACTIVATION; VALIDITY;

D O I：

10.1016/j.psyneuen.2018.03.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The endocannabinoid (EC) system influences a wide variety of neurobiological processes including affect and emotionality as well as other neuropsychiatric functions. In this study we examined the relationship of circulating endocannabinoids [anandamide (AEA) and 2-arachidonoylglycerol (2-AG)] with affect and emotionality in 175 individuals with (n = 115) and without (n = 60) mood, anxiety, and/or personality disorders. Circulating AEA levels displayed a modest, though statistically significant, inverse relationship with a composite measure of affect regulation (beta = - 0.264, p = 0.009), due to its relationship with affect intensity (beta = - 0.225, p = 0.021) across all study participants. Neither AEA nor 2-AG level differed as a function of any syndromal/personality disorder and neither correlated significantly with state depression or state anxiety scores. These data suggest that circulating levels endocannabinoids may play a role in emotionality across individuals regardless of defined psychiatric disorder.

引用

页码：66 / 71

页数：6

共 45 条

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[Anonymous], NEUROPSYCHOPHARMACOL

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