Vaccine strain Listeria monocytogenes bacteremia occurring 31 months after immunization

被引：16

作者：

Fares, Elias ^{[1
]}

McCloskey, Cindy B. ^{[2
]}

Gutierrez, Andres ^{[3
]}

Princiotta, Michael ^{[3
]}

Salinas, Linda J. ^{[1
]}

Drevets, Douglas A. ^{[1
,4
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Internal Med, Sect Infect Dis, 800 Stanton L Young Blvd,Suite 7300, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, Oklahoma City, OK USA

[3] Advaxis Inc, Princeton, NJ USA

[4] US Dept Vet Affairs, Med Serv, Med Ctr, Oklahoma City, OK 73111 USA

来源：

INFECTION | 2019年 / 47卷 / 03期

关键词：

Immunotherapy; Live vaccine; Recurrent listeriosis; Listeria vaccine; INFECTION;

D O I：

10.1007/s15010-018-1249-7

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

BackgroundListeria monocytogenes is a food-borne, facultative intracellular bacterium that causes severe diseases such as sepsis and meningoencephalitis in immunocompromised hosts. Because it stimulates robust T-lymphocyte-mediated responses, attenuated L. monocytogenes are candidate vaccine vectors for tumor immunotherapy.CaseWe report a case of bacteremia caused by vaccine strain L. monocytogenes (Axalimogene filolisbac) occurring 31 months after immunization against human papilloma virus (HPV) associated cervical cancer.ConclusionReceipt of a L. monocytogenes-based vaccine is a novel risk factor for delayed L. monocytogenes bacteremia.

引用

页码：489 / 492

页数：4

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