Abnormal Cervical Cytology After Allogeneic Bone Marrow Transplantation

被引:5
作者
Negri, Giovanni [1 ]
Herz, Martina [1 ]
Deola, Sara [2 ]
Piccin, Andrea [2 ]
Casini, Marco [2 ]
Babich, Bianca
Tauber, Martina [1 ]
Messini, Sergio [3 ]
Marucci, Maria Raffaella [4 ]
Vittadello, Fabio [5 ]
机构
[1] Cent Hosp Bolzano, Dept Pathol, I-39100 Bolzano, Italy
[2] Cent Hosp Bolzano, Hematol & BMT Dept, I-39100 Bolzano, Italy
[3] Cent Hosp Bolzano, Dept Gynecol & Obstet, I-39100 Bolzano, Italy
[4] Univ Brescia, Spedali Civili, Dept Pathol 1 & 2, Brescia, Italy
[5] Explora Res & Stat Anal, Padua, Italy
关键词
Bone marrow transplantation; Cervical cytology; Pap smear; Busulfan; Atypia; STEM-CELL TRANSPLANTATION; LONG-TERM SURVIVORS; DYSPLASIA; RECIPIENTS; BUSULFAN; ATYPIA;
D O I
10.1309/AJCP4SKAUS9TOTJX
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Objectives: Allogeneic bone marrow transplantation (BMT) is a procedure mostly used for high-risk hematologic malignances. In women, follow-up protocols after BMT include gynecologic checkups with Papanicolaou (Pap) smears. Methods: We evaluated 117 Pap smears in 54 women who underwent allogeneic BMT and correlated the smear morphology with the BMT-related medical treatment. Results: Abnormal Pap smears after BMT were found in 13 (24.1%) women. Four (7.4%) women had at least one smear with atypical squamous cells of unknown significance, six (11.1%) had a low-grade squamous intraepithelial lesion, and three (5.6%) had atypical squamous cells/high-grade lesion cannot be excluded (ASC-H). The three patients with ASC-H showed high-grade atypia mimicking cancer but had a negative follow-up. Nine women, including the three with ASC-H, had undergone a conditioning therapy for BMT that included busulfan. No association between other drugs and therapy-related atypia was found. Conclusions: Pap smears after BMT show a high incidence of dysplastic lesions. Moreover, conditioning including busulfan is often associated with therapy-related cytologic atypia, which may lead to unnecessary colposcopies and biopsies. Knowledge of the patient's history and a careful evaluation of the smears are mandatory in these cases.
引用
收藏
页码:222 / 226
页数:5
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