ABCC8 genetic variants and risk of diabetes mellitus

被引：35
作者：
Haghverdizadeh, Polin [1 ]
Haerian, Monir Sadat [2 ]
Haghverdizadeh, Pantea [3 ]
Haerian, Batoul Sadat [4 ]
机构：
[1] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Biomed Sci, Kuala Lumpur, Malaysia
[2] Minist Hlth, FDCL, Tehran, Iran
[3] Azad Univ, Fac Sci, Dept, East Branch, Tehran, Iran
[4] Univ Malaya, Fac Med, Dept Pharmacol, Kuala Lumpur 50603, Malaysia
来源：
GENE | 2014年 / 545卷 / 02期
关键词：
Diabetes mellitus; ABCC8; Polymorphism; BETA-CELL FUNCTION; SINGLE NUCLEOTIDE POLYMORPHISMS; SENSITIVE POTASSIUM CHANNEL; RECEPTOR; GENE; SULFONYLUREA RECEPTOR; INSULIN-SECRETION; SEQUENCE VARIANTS; PHYSICAL-ACTIVITY; SUR1; TYPE-2;
D O I：
10.1016/j.gene.2014.04.040
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Diabetes mellitus (DM) is a major health problem worldwide and it will rapidly increase. This disease is characterized by hyperglycemia caused by defects in insulin secretion, insulin action or both. DM has three types: T1DM, T2M and gestational DM (GDM), of them T2DM is more frequent. Multiple genes and their interactions are involved in insulin secretion pathway. Sulfonylurea receptor encoded by ABCC8 gene, together with inward-rectifier potassium ion channel (Kir6.2) regulates insulin secretion by ATP-sensitive K+ (KATP) channel located in the plasma membranes. Disruption of these molecules by different mutations is responsible for risk of DM. Several single nucleotide polymorphisms (SNPs) of ABCC8 gene and their interaction are involved in pathogenicity of DM. This review summarizes the current evidence of contribution of ABC8 genetic variants to the development of DM. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：198 / 204
页数：7
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