Lipoyl synthase inserts sulfur atoms into an octanoyl substrate in a stepwise manner

被引：54

作者：

Douglas, Paid ^{[1
]}

Kriek, Marco ^{[1
]}

Bryant, Penny ^{[1
]}

Roach, Peter L. ^{[1
]}

机构：

[1] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 31期

关键词：

biosynthesis; cofactors; enzyme models; insertion; lipoic acid;

D O I：

10.1002/anie.200601910

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) One step at a time: The insertion of the two sulfur atoms found in lipoyl groups requires the enzyme lipoyl synthase (LipA). The order of insertion of the two sulfur groups has been elucidated by spectroscopic characterization of a monothiolated species. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5197 / 5199

页数：3

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