A new function for miRNAs as regulators of autophagy

被引：23
作者：
Aredia, Francesca [1 ]
Scovassi, Anna Ivana [1 ]
机构：
[1] CNR, Ist Genet Mol, Via Abbiategrasso 207, I-27100 Pavia, Italy
来源：
FUTURE MEDICINAL CHEMISTRY | 2017年 / 9卷 / 01期
关键词：
antagomir; autophagy; biomarker; cancer; miRNA; oncomiR; tumor suppressor miRNA; CANCER STEM-CELLS; TUMOR SUPPRESSIVE ROLES; COLORECTAL-CANCER; HEPATOCELLULAR-CARCINOMA; DOWN-REGULATION; CIRCULATING MICRORNAS; PROMOTES AUTOPHAGY; SIGNALING NETWORKS; HUMAN GLIOBLASTOMA; SMALL MOLECULES;
D O I：
10.4155/fmc-2016-0173
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Autophagy is a self-digestive process regulated by an intricate network of factors able either to ensure the prosurvival function of autophagy or to convert it in a death pathway. Recently, the involvement of miRNAs in the regulation of autophagy networks has been reported. This review will summarize the main features of these small noncoding endogenous RNAs, focusing on their relevance in cancer and finally addressing their impact on autophagy.
引用
收藏
页码：25 / 36
页数：12
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