Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab

被引：54

作者：

Hakozaki, Michiyuki ^{[1
]}

Tajino, Takahiro ^{[1
]}

Yamada, Hitoshi ^{[1
]}

Hasegawa, Osamu ^{[2
]}

Tasaki, Kazuhiro ^{[3
]}

Watanabe, Kazuo ^{[4
]}

Konno, Shinichi ^{[1
]}

机构：

[1] Fukushima Med Univ, Sch Med, Dept Orthopaed Surg, Fukushima 9601295, Japan

[2] Fukushima Med Univ, Sch Med, Dept Radiol, Fukushima 9601295, Japan

[3] Fukushima Med Univ, Sch Med, Dept Pathol & Diagnost Pathol, Fukushima 9601295, Japan

[4] Fukushima Pathol Lab, Fukushima, Japan

来源：

DIAGNOSTIC PATHOLOGY | 2014年 / 9卷

关键词：

Giant cell tumor of bone; Denosumab; Neoadjuvant chemotherapy; Receptor activator of nuclear factor-kappa B ligand (RANKL); Plain radiograph; MRI; F-18-FDG PET/CT; Benign fibrous histiocytoma;

D O I：

10.1186/1746-1596-9-111

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We describe a case of giant cell tumor of the proximal tibia with skip bone metastases of the ipsilateral femur in a 20-year-old man. After the neoadjuvant treatment with denosumab, plain radiographs and computed tomography showed marked osteosclerosis and sclerotic rim formation, and F-18-FDG PET/CT showed a decreased standardized uptake value, whereas magnetic resonance imaging showed diffuse enhancement of the tumor, nearly the same findings as those at pretreatment. Pathological findings of the surgical specimen after the denosumab treatment showed benign fibrous histiocytoma-like features with complete disappearance of both mononuclear stromal cells and multinuclear osteoclast-like giant cells. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1090602085125068

引用

页数：6

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