Edible bird's nest extract inhibits influenza virus infection

被引：178

作者：

Guo, Chao-Tan

Takahashi, Tadanobu

Bukawa, Wakoto

Takahashi, Noriko

Yagi, Hirokazu

Kato, Koichi

Hidari, Kazuya I. -P. Jwa

Miyamoto, Daisei

Suzuki, Takashi

Suzuki, Yasuo ^{[1
]}

机构：

[1] Univ Shizuoka, Dept Biochem, Sch Pharmaceut Sci, Suruga Ku, Shizuoka 4228526, Japan

[2] COE Program 21st Century, Suruga Ku, Shizuoka 4228526, Japan

[3] Zhejiang Acad Med Sci, Inst Bioengn, Hangzhou 310013, Peoples R China

[4] Nagoya City Univ, Fac Pharmaceut Sci, Nagoya, Aichi 4678601, Japan

来源：

ANTIVIRAL RESEARCH | 2006年 / 70卷 / 03期

基金：

日本学术振兴会;

关键词：

influenza; bird nest; sialic acid;

D O I：

10.1016/j.antiviral.2006.02.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Edible bird's nest (EBN) is the nest of the swift that is made from its saliva. Although EBN has been widely used for enhancing immunocompetence, its antiviral efficacy has not been studied in detail. We found that EBN extract could strongly inhibit infection with influenza viruses in a host range-independent manner when it was hydrolyzed with Pancreatin F. Western blotting assay showed that the EBN extract bound to influenza virus. Furthermore, EBN extract could neutralize the infection of MDCK cells with influenza viruses and inhibit hemagglutination of influenza viruses to erythrocytes, but it could not inhibit the activity of influenza virus sialidase. Fluorometric HPLC indicated that the major molecular species of sialic acid in EBN is N-acetylneuraminic acid. The results suggest that EBN is a safe and valid natural source for the prevention of influenza viruses. (c) 2006 Elsevier B.V. All rights reserved.

引用

收藏

页码：140 / 146

页数：7

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