Gender differences in expression of organic cation transporter OCT2 rat kidney

被引：130

作者：

Urakami, Y ^{[1
]}

Nakamura, N ^{[1
]}

Takahashi, K ^{[1
]}

Okuda, M ^{[1
]}

Saito, H ^{[1
]}

Hashimoto, Y ^{[1
]}

Inui, K ^{[1
]}

机构：

[1] Kyoto Univ, Fac Med, Kyoto Univ Hosp, Dept Pharm,Sakyo Ku, Kyoto 6068507, Japan

来源：

FEBS LETTERS | 1999年 / 461卷 / 03期

关键词：

organic cation transporter; tetraethylammonium; basolateral membrane; renal tubular secretion; (rat kidney);

D O I：

10.1016/S0014-5793(99)01491-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The organic cation transporter (OCT) mediates translocation of various cationic molecules including drugs, toxins and endogenous substances. We examined gender differences in the expression of rat (r) OCT2 in the kidney. Slices and basolateral membrane vesicles of male rat kidney showed a higher transport activity for tetraethylammonium than those of female rat kidney. The expression levels of rOCT2 mRNA and protein in the kidney of males were much higher than those in females. There was no gender difference in mRNA expression of rOCT1 and rOCT3. These findings suggest that rOCT2 is responsible for the gender differences in renal basolateral membrane organic cation transport activity. (C) 1999 Federation of European Biochemical Societies.

引用

页码：339 / 342

页数：4

共 28 条

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