Involvement of PKA, PKC, CAMK-II and MEK1/2 in the acute antidepressant-like effect of creatine in mice

被引：21

作者：

Cunha, Mauricio P. ^{[1
]}

Budni, Josiane ^{[1
]}

Pazini, Francis L. ^{[1
]}

Oliveira, Agatha ^{[1
]}

Rosa, Julia M. ^{[1
]}

Lopes, Mark W. ^{[1
]}

Leal, Rodrigo B. ^{[1
]}

Rodrigues, Ana Lucia S. ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Dept Biochem, Florianopolis, SC, Brazil

来源：

PHARMACOLOGICAL REPORTS | 2014年 / 66卷 / 04期

关键词：

Antidepressant; Creatine; Intracellular signaling; Kinases; Tail suspension test; ACTIVATED PROTEIN-KINASE; INHIBITOR; ALPHA(1)-ADRENOCEPTORS; MONOHYDRATE; RECEPTOR;

D O I：

10.1016/j.pharep.2014.03.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: The aim of this study was to investigate the involvement of signaling pathways on the creatine antidepressant-like effect in the tail suspension test (TST) in mice. Methods: The TST was used to assess the antidepressant-like properties of creatine. Results: The anti-immobility effect of creatine (1 mg/kg, p.o.) in the TST was blocked by i.c.v. pretreatment with H-89 (1 mu g/site, PKA inhibitor), KN-62 (1 mu g/site, CAMK-II inhibitor), chelerythrine (1 mu g/site, PKC inhibitor), U0126 (5 mu g/site, MEK1/2 inhibitor) or P009058 (5 mu g/site, MEK1/2 inhibitor). Conclusion: These results suggest that the antidepressant-like effect of creatine is dependent on PKA, CaMK-II, PKC and MEK 1/2 activation. (C) 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. Z o.o. All rights reserved.

引用

页码：653 / 659

页数：7

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