The Role of Platelet-Derived Growth Factor in the Pathogenesis of Sinonasal Polyps: Immunohistochemical Assessment in Epithelial, Subepithelial and Deep Layers of the Mucosa

被引:6
作者
Muluk, Nuray Bayar [1 ]
Arikan, Osman Kursat [2 ]
Atasoy, Pinar [3 ]
Kilic, Rahmi [1 ]
Yalcinozan, Eda Tuna [4 ]
机构
[1] Kirikkale Univ, Fac Med, ENT Dept, Kirikkale, Turkey
[2] Adana Numune Educ & Training Hosp, ENT Dept, Adana, Turkey
[3] Kirikkale Univ, Fac Med, Dept Pathol, Kirikkale, Turkey
[4] Artvin State Hosp, ENT Dept, Artvin, Turkey
关键词
Sinonasal polyp; Pathogenesis; Platelet-derived growth factor; Perivascular; Endothelial; NASAL POLYPOSIS; FACTOR B; PDGF-B; EXPRESSION; CHILDREN; AGE;
D O I
10.3342/ceo.2013.6.3.152
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Objectives:The aim of this study is to investigate the role of platelet-derived growth factor (PDGF) in the pathogenesis of sinonasal polyps. Methods. Study group (groups 1-3) consisted of nasal polyp samples of patients with sinonasal polyps and the control group consisted of inferior turbinate samples of patients without nasal polyp. In group 1, 14 specimens from ethmoid sinus; in group 2,10 specimens from nasal cavity; in group 3,10 specimens from maxillary sinus; and in group 4 (control), 9 specimens from inferior turbinate were included. By immunohistochemical staining technique, the PDGF positivity index (PI) in mucosal layers and in the inflammatory cells were assessed at the epithelium (EP), subepithelial layer of lamina propria (SE), and deep paraglandular layer of the mucosa (D). Results. Polymorphonudear cell (PMNC)-percentage (%) values of ethmoid and maxillary sinus, and the PDGF PI from all cells of ethmoid sinus and nasal cavity were significantly higher than those of the control group. As mononuclear cell-% (MNC-%) increased, the PDGF_EP_basal PI, PDGF_SE_endothelial PI, and PDGF_D_endothelial PI decreased. As PMNC-PDGF PI increased, the PDGF_D_perivascular PI decreased and PDGF_D_endothelial PI increased. As PDGF-MNC PI increased, the PDGF_EP_apical PI, PDGF_SE_endothelial PI, and PDGF_D_endothelial PI decreased. As PDGF-all cells (PMNCs, MNCs, and fibroblasts) PI increased, the PDGF_EP_basal PI and PDGF_D_endothelial PI decreased, and the PDGF_D_perivascular PI increased. Conclusion. We concluded that the PDGF systems play important roles in polyp pathogenesis. Fibroblast-derived PDGF may be more important than MNC-derived PDGF in polyp developing process. Increased perivascular-PDGF-PI in deep layers of the mucosa may result in sinonasal polyp formation by causing an increase in vascular permeability and extracellular edema, and thus promoting migration of inflammatory cells to extracellular area. Tissue oxygenization may be important for the initiation of PDGF release system. Because of this reason, nasal obstruction should be medically treated earlier, and, if necessary, by surgical approaches.
引用
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页码:152 / 160
页数:9
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