Screening for HIV-related neurocognitive impairment in clinical practice: Challenges and opportunities

被引：11

作者：

Barber, T. J. ^{[1
]}

Bradshaw, D. ^{[1
,2
]}

Hughes, D. ^{[3
]}

Leonidou, L. ^{[1
,4
]}

Margetts, A. ^{[5
]}

Ratcliffe, D. ^{[5
]}

Thornton, S. ^{[5
]}

Pozniak, A. ^{[1
]}

Asboe, D. ^{[1
]}

Mandalia, S. ^{[3
]}

Boffito, M. ^{[1
]}

Davies, N. ^{[6
]}

Gazzard, B. ^{[1
]}

Catalan, J. ^{[5
]}

机构：

[1] Chelsea & Westminster Hosp NHS Fdn Trust, St Stephens Ctr, London, England

[2] Univ New S Wales, Kirby Inst Infect & Immun Soc, Sydney, NSW, Australia

[3] Univ London Imperial Coll Sci Technol & Med, London, England

[4] Patras Univ Hosp, Dept Infect Dis, Patras, Greece

[5] Cent & North West London NHS Fdn Trust, South Kensington & Chelsea Mental Hlth Ctr, London, England

[6] Chelsea & Westminster Hosp NHS Fdn Trust, Dept Neurol, London, England

来源：

AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV | 2014年 / 26卷 / 02期

关键词：

HIV; neurocognitive impairment; screening; AIDS DEMENTIA COMPLEX; COGNITIVE IMPAIRMENT; ADVERSE EVENTS; ERA; DISORDERS; VALIDITY; VALIDATION; IMPACT; SCALE; IMPROVEMENT;

D O I：

10.1080/09540121.2013.819401

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

With increasingly successful management of HIV, focus has shifted away from AIDS-related complications to other chronic co-morbidities. For HIV-related cognitive problems, the true aetiopathogenesis and epidemiology remains unclear. Rather than a systematic review, this paper presents the challenges and the opportunities we faced in establishing our own clinical service. Papers were identified using Pubmed and the terms screening, HIV and neurocognitive. This article covers the background of HIV-associated neurocognitive disorders (HAND) with a focus on HIV-related neurocognitive impairment (NCI), detailing classification, prevalence, diagnostic categories and diagnostic uncertainties. Screening is discussed, including a comparison of the available screening tools for cognitive deficits in HIV-infected patients and the importance of practice effects. Discussed also are the normal ranges and the lack thereof and potential investigations for those found to have impairments. We conclude by discussing the role of NCI screening in routine clinical care at the current time.

引用

页码：160 / 168

页数：9

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