Consortium to Establish a Registry for Alzheimer's Disease;
Cognitive abilities screening instrument;
Cognitive ageing;
Education;
VERBAL FLUENCY TESTS;
ALZHEIMERS-DISEASE;
NORMATIVE DATA;
IMPAIRMENT;
POPULATION;
DEMENTIA;
DECLINE;
CERAD;
CONSORTIUM;
EDUCATION;
D O I:
10.1159/000495657
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Background/Aims: To detect cognitive decline in older adults, measures of verbal fluency and verbal memory are widely used. Less is known about performance in these measures in younger persons or according to education level and gender. We investigated cognitive performance according to age, education and gender among cognitively healthy adults aged 30-100 years. Methods: The study population comprised 4,174 cognitively healthy persons participating in the nationally representative Finnish Health 2011 survey. Cognitive assessment included verbal fluency, word list memory, word list recall and word list savings from the Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery. Results: Total variance in the cognitive test performance explained by age, education and gender varied from 12.3 to 31.2%. A decreasing trend in cognitive performance existed in all subtests by advancing age, with differences appearing between 50 and 55 years. Persons with the highest-education level performed best for all measures. For the participants < 55 years, education explained part of the variance, while age and gender did not. Conclusions: When assessing cognition, age and education should be accounted for in more detail in research and clinical practice. Additionally, the cohort effect and its potential impact on the renewal cycle of future normative values for cognitive tests should be considered. (C) 2019 The Author(s) Published by S. Karger AG, Basel
机构:
Univ Michigan, Dept Neurol, Michigan Alzheimers Dis Ctr, Ann Arbor, MI USA
Oregon Hlth & Sci Univ, Dept Neurol, Layton Aging & Alzheimers Dis Ctr, Portland, OR 97201 USAUniv Michigan, Dept Neurol, Michigan Alzheimers Dis Ctr, Ann Arbor, MI USA
Dodge, Hiroko H.
;
Zhu, Jian
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USAUniv Michigan, Dept Neurol, Michigan Alzheimers Dis Ctr, Ann Arbor, MI USA
Zhu, Jian
;
Hughes, Tiffany F.
论文数: 0引用数: 0
h-index: 0
机构:
Youngstown State Univ, One Univ Plaza, Youngstown, OH 44555 USAUniv Michigan, Dept Neurol, Michigan Alzheimers Dis Ctr, Ann Arbor, MI USA
Hughes, Tiffany F.
;
Snitz, Beth E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USAUniv Michigan, Dept Neurol, Michigan Alzheimers Dis Ctr, Ann Arbor, MI USA
Snitz, Beth E.
;
Chang, Chung-Chou H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15213 USA
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15261 USAUniv Michigan, Dept Neurol, Michigan Alzheimers Dis Ctr, Ann Arbor, MI USA
Chang, Chung-Chou H.
;
Jacobsen, Erin P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USAUniv Michigan, Dept Neurol, Michigan Alzheimers Dis Ctr, Ann Arbor, MI USA
Jacobsen, Erin P.
;
Ganguli, Mary
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA
Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USAUniv Michigan, Dept Neurol, Michigan Alzheimers Dis Ctr, Ann Arbor, MI USA
机构:
Univ Michigan, Dept Neurol, Michigan Alzheimers Dis Ctr, Ann Arbor, MI USA
Oregon Hlth & Sci Univ, Dept Neurol, Layton Aging & Alzheimers Dis Ctr, Portland, OR 97201 USAUniv Michigan, Dept Neurol, Michigan Alzheimers Dis Ctr, Ann Arbor, MI USA
Dodge, Hiroko H.
;
Zhu, Jian
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USAUniv Michigan, Dept Neurol, Michigan Alzheimers Dis Ctr, Ann Arbor, MI USA
Zhu, Jian
;
Hughes, Tiffany F.
论文数: 0引用数: 0
h-index: 0
机构:
Youngstown State Univ, One Univ Plaza, Youngstown, OH 44555 USAUniv Michigan, Dept Neurol, Michigan Alzheimers Dis Ctr, Ann Arbor, MI USA
Hughes, Tiffany F.
;
Snitz, Beth E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USAUniv Michigan, Dept Neurol, Michigan Alzheimers Dis Ctr, Ann Arbor, MI USA
Snitz, Beth E.
;
Chang, Chung-Chou H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15213 USA
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15261 USAUniv Michigan, Dept Neurol, Michigan Alzheimers Dis Ctr, Ann Arbor, MI USA
Chang, Chung-Chou H.
;
Jacobsen, Erin P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USAUniv Michigan, Dept Neurol, Michigan Alzheimers Dis Ctr, Ann Arbor, MI USA
Jacobsen, Erin P.
;
Ganguli, Mary
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA
Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USAUniv Michigan, Dept Neurol, Michigan Alzheimers Dis Ctr, Ann Arbor, MI USA