Oral administration of probiotic bacteria (E-coli Nissle, E-coli O83, Lactobacillus casei) influences the severity of dextran sodium sulfate-induced colitis in BALB/c mice

被引：51

作者：

Kokesova, A. ^{[1
]}

Frolova, L.

Kverka, M.

Sokol, D.

Rossmann, P.

Bartova, J.

Tlaskalova-Hogenova, H.

机构：

[1] Univ Children Hosp Motol, Clin Pediat Surg, Prague 15006, Czech Republic

[2] Acad Sci Czech Republ, Inst Microbiol, Dept Immunol & Gnotobiol, Prague, Czech Republic

[3] Charles Univ Prague, Med Fac 1, Inst Dent Res, Prague, Czech Republic

[4] Gen Fac Hosp, Prague, Czech Republic

来源：

FOLIA MICROBIOLOGICA | 2006年 / 51卷 / 05期

关键词：

D O I：

10.1007/BF02931595

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Our study examined whether repeated preventive oral administration of live probiotic bacterial strains Escherichia coli O83:K24:H31 (Ec O83), Escherichia coli Nissle 1917 O6:K5:H1 (Ec Nis) and Lactobacillus casei DN 114001 (Lc) can protect mice against dextran sodium sulfate (DSS)-induced colitis. A significant decrease in average symptom score was observed in Ec O83-, Ec Nis- and Lc-pretreated group (p < 0.05). Significant differences in body mass loss between Lc pretreated mice with DSS-induced colitis were found when compared with nontreated mice (p < 0.05). PBS pretreated mice had a significantly shorter colon than Ec O83-, Ec Nis- and Lc-pretreated mice (p < 0.05). Administration of Lc significantly decreased the severity of DSS induced histological marks of inflammation (p < 0.05). A significant difference (p < 0.05) was also found in specific IgA level against given probiotic in enteral fluid between colitic mice and healthy mice pretreated with Ec O83 and Ec Nis.

引用

页码：478 / 484

页数：7

共 36 条

[1] Intercellular adhesion molecule-1 (ICAM-1) deficiency protects mice against severe forms of experimentally induced colitis [J].

Bendjelloul, F ;

Maly, P ;

Mandys, V ;

Jirkovská, M ;

Prokesová, L ;

Tucková, L ;

Tlaskalová-Hogenová, H .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2000, 119 (01) :57-63

[2] Aggregation of Lactobacilli and Bifidobacteria with Escherichia coli O157 [J].

Bujnáková, D ;

Vlková, E ;

Rada, V ;

Kmet, V .

FOLIA MICROBIOLOGICA, 2004, 49 (02) :143-146

[3]

Cebra JJ, 2005, MUCOSAL IMMUNOLOGY, 3RD EDITION, P335, DOI 10.1016/B978-012491543-5/50022-X

[4]

COOPER HS, 1993, LAB INVEST, V69, P238

[5] Specific proliferative and antibody responses of premature infants to intestinal colonization with nonpathogenic probiotic E-coli strain Nissle 1917 [J].

Cukrowska, B ;

Lodínova-Zádníková, R ;

Enders, C ;

Sonnenborn, U ;

Schulze, J ;

Tlaskalová-Hogenová, H .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2002, 55 (02) :204-209

[6] DEXTRAN SULFATE SODIUM-INDUCED COLITIS OCCURS IN SEVERE COMBINED IMMUNODEFICIENT MICE [J].

DIELEMAN, LA ;

RIDWAN, BU ;

TENNYSON, GS ;

BEAGLEY, KW ;

BUCY, RP ;

ELSON, CO .

GASTROENTEROLOGY, 1994, 107 (06) :1643-1652

[7]

Duchmann R, 1995, CLIN EXP IMMUNOL, V102, P448

[8] The role of microflora in the development of intestinal inflammation:: Acute and chronic colitis induced by dextran sulfate in germ-free and conventionally reared immunocompetent and immunodeficient mice [J].

Hudcovic, T ;

Stepánková, R ;

Cebra, J ;

Tlaskalová-Hogenová, H .

FOLIA MICROBIOLOGICA, 2001, 46 (06) :565-572

[9] Bifidobacterium bifidum monoassociation of gnotobiotic mice:: Effect on enterocyte brush-border enzymes [J].

Kozáková, H ;

Reháková, Z ;

Kolínská, J .

FOLIA MICROBIOLOGICA, 2001, 46 (06) :573-576

[10] Maintenance of remission in ulcerative colitis is equally effective with Escherichia coli Nissle 1917 and with standard mesalamine [J].

Kruis, W ;

Fric, P ;

Stolte, MS .

GASTROENTEROLOGY, 2001, 120 (05) :A127-A127

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