Regulating actin-filament dynamics in vivo

被引：218

作者：

Chen, H ^{[1
]}

Bernstein, BW

Bamburg, JR

机构：

[1] Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA

[2] Colorado State Univ, Mol Cellular & Integrat Neurosci Program, Ft Collins, CO 80523 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 01期

关键词：

D O I：

10.1016/S0968-0004(99)01511-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The assembly and disassembly (i.e. turnover) of actin filaments in response to extracellular signals underlie a wide variety of basic cellular processes such as cell division, endocytosis and motility. The bulk turnover of subunits is 100-200 times faster in cells than with pure actin, suggesting a complex regulation in vivo. Significant progress has been made recently in identifying and clarifying the roles of several cellular proteins that coordinately regulate actin-filament turnover.

引用

页码：19 / 23

页数：5

共 53 条

[41] THE BULK OF UNPOLYMERIZED ACTIN IN XENOPUS EGG EXTRACTS IS ATP-BOUND [J].

ROSENBLATT, J ;

PELUSO, P ;

MITCHISON, TJ .

MOLECULAR BIOLOGY OF THE CELL, 1995, 6 (02) :227-236

[42] Xenopus actin depolymerizing factor cofilin (XAC) is responsible for the turnover of actin filaments in Listeria monocytogenes tails [J].

Rosenblatt, J ;

Agnew, BJ ;

Abe, H ;

Bamburg, JR ;

Mitchison, TJ .

JOURNAL OF CELL BIOLOGY, 1997, 136 (06) :1323-1332

[43] Control of actin assembly at filament ends [J].

Schafer, DA ;

Cooper, JA .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1995, 11 :497-518

[44] Visualization and molecular analysis of actin assembly in living cells [J].

Schafer, DA ;

Welch, MD ;

Machesky, LM ;

Bridgman, PC ;

Meyer, SM ;

Cooper, JA .

JOURNAL OF CELL BIOLOGY, 1998, 143 (07) :1919-1930

[45]

SUMI T, IN PRESS J CELL BIOL

[46] ACTIN MONOMER BINDING-PROTEINS [J].

SUN, HQ ;

KWIATKOWSKA, K ;

YIN, HL .

CURRENT OPINION IN CELL BIOLOGY, 1995, 7 (01) :102-110

[47] Arp2/3 complex and actin depolymerizing factor cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia [J].

Svitkina, TM ;

Borisy, GG .

JOURNAL OF CELL BIOLOGY, 1999, 145 (05) :1009-1026

[48] Progress in protrusion: the tell-tale scar [J].

Svitkina, TM ;

Borisy, GG .

TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (11) :432-436

[49] TREADMILLING OF ACTIN AT PHYSIOLOGICAL SALT CONCENTRATIONS - AN ANALYSIS OF THE CRITICAL CONCENTRATIONS OF ACTIN-FILAMENTS [J].

WEGNER, A .

JOURNAL OF MOLECULAR BIOLOGY, 1982, 161 (04) :607-615

[50]

Weinberger R, 1996, J NEUROSCI, V16, P238

← 1 2 3 4 5 6 →