Biomarkers of aging and falling: The Beaver Dam eye study

Falls are an important cause of morbidity in older adults and are an important source of health care spending. We hypothesize that falls are associated with systemic biomarkers of aging. The following functions, measured at the 1998-2000 and 2003-2005 examinations of the Beaver Dam eye study, were considered to be biomarkers of aging (frailties): poorer visual acuity, contrast sensitivity or discrepant vision between the eyes, inability to rise from a chair, slower gait time, poorer hand grip strength, and lower peak expiratory flow rate. We found that poorer values on biomarkers of aging (frailties) at the 1998-2000 examination were associated with two or more reported falls in the past year at the 20032005 examination (p < 0.05 for all markers except peak expiratory flow rate). When the markers were combined as an index of biological aging (frailty), the index was significantly associated with falls after controlling for significant confounders (odds ratio per one step increase in the index: 1.33: 95% confidence interval = Cl = 1.13-1.57). We conclude that biomarkers of aging, including any of three measures of visual function, are associated with falls. Improvement in these functional measures may lead to decreased risk of falls. (C) 2008 Elsevier Ireland Ltd. All rights reserved.