Acid Base Balance and Progression of Kidney Disease

被引：20
作者：
Chen, Wei [1 ,2 ]
Levy, David S. [2 ]
Abramowitz, Matthew K. [1 ]
机构：
[1] Albert Einstein Coll Med, Nephrol Div, Dept Med, Bronx, NY 10461 USA
[2] Univ Rochester, Sch Med & Dent, Dept Med, Nephrol Div, Rochester, NY USA
来源：
SEMINARS IN NEPHROLOGY | 2019年 / 39卷 / 04期
基金：
美国国家卫生研究院;
关键词：
Renal insufficiency; chronic; acidosis; alkalosis; alkali therapy; kidney disease progression; GLOMERULAR-FILTRATION-RATE; RENAL AMMONIA METABOLISM; LONG-TERM OUTCOMES; URINE ANION GAP; SERUM BICARBONATE; DIETARY ACID; TGF-BETA; CKD; ENDOTHELIN; DECLINE;
D O I：
10.1016/j.semnephrol.2019.04.009
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
A large body of work in animals and human beings supports the hypothesis that metabolic acidosis has a deleterious effect on the progression of kidney disease. Alkali therapy, whether pharmacologically or through dietary intervention, appears to slow CKD progression, but an appropriately powered randomized controlled trial with a low risk of bias is required to reach a more definitive conclusion. Recent work on urinary ammonium excretion has shown that the development of prognostic tools related to acidosis is not straightforward, and that application of urine markers such as ammonium may require more nuance than would be predicted based on our understanding of the pathophysiology. (C) 2019 Elsevier Inc. All rights reserved.
引用
收藏
页码：406 / 417
页数：12
相关论文
共 67 条
  • [1] The serum anion gap is altered in early kidney disease and associates with mortality
    Abramowitz, Matthew K.
    Hostetter, Thomas H.
    Melamed, Michal L.
    [J]. KIDNEY INTERNATIONAL, 2012, 82 (06) : 701 - 709
  • [2] Regression of existing glomerulosclerosis by inhibition of aldosterone
    Aldigier, JC
    Kanjanbuch, T
    Ma, LJ
    Brown, NJ
    Fogo, AB
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 (11): : 3306 - 3314
  • [3] High Dietary Acid Load Predicts ESRD among Adults with CKD
    Banerjee, Tanushree
    Crews, Deidra C.
    Wesson, Donald E.
    Tilea, Anca M.
    Saran, Rajiv
    Rios-Burrows, Nilka
    Williams, Desmond E.
    Powe, Neil R.
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2015, 26 (07): : 1693 - 1700
  • [4] TGF-β in renal injury and disease
    Bottinger, Erwin P.
    [J]. SEMINARS IN NEPHROLOGY, 2007, 27 (03) : 309 - 320
  • [5] EFFECT OF REDUCED RENAL MASS ON AMMONIUM HANDLING AND NET ACID FORMATION BY THE SUPERFICIAL AND JUXTAMEDULLARY NEPHRON OF THE RAT - EVIDENCE FOR IMPAIRED REENTRAPMENT RATHER THAN DECREASED PRODUCTION OF AMMONIUM IN THE ACIDOSIS OF UREMIA
    BUERKERT, J
    MARTIN, D
    TRIGG, D
    SIMON, E
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1983, 71 (06) : 1661 - 1675
  • [6] Impaired expression of key molecules of ammoniagenesis underlies renal acidosis in a rat model of chronic kidney disease
    Buerki, Remy
    Mohebbi, Nilufar
    Bettoni, Carla
    Wang, Xueqi
    Serra, Andreas L.
    Wagner, Carsten A.
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2015, 30 (05) : 770 - 781
  • [7] Randomized, Controlled Trial of TRC101 to Increase Serum Bicarbonate in Patients with CKD
    Bushinsky, David A.
    Hostetter, Thomas
    Klaerner, Gerrit
    Stasiv, Yuri
    Lockey, Claire
    McNulty, Sarah
    Lee, Angela
    Parsell, Dawn
    Mathur, Vandana
    Li, Elizabeth
    Buysse, Jerry
    Alpern, Robert
    [J]. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2018, 13 (01): : 26 - 35
  • [8] Epidemiology of Acid-Base Derangements in CKD
    Chen, Wei
    Abramowitz, Matthew K.
    [J]. ADVANCES IN CHRONIC KIDNEY DISEASE, 2017, 24 (05) : 280 - 288
  • [9] Metabolic acidosis and the progression of chronic kidney disease
    Chen, Wei
    Abramowitz, Matthew K.
    [J]. BMC NEPHROLOGY, 2014, 15
  • [10] Cochrane, COCHR RISK BIAS TOOL
1234567