Acid Base Balance and Progression of Kidney Disease

被引：21

作者：

Chen, Wei ^{[1
,2
]}

Levy, David S. ^{[2
]}

Abramowitz, Matthew K. ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Nephrol Div, Dept Med, Bronx, NY 10461 USA

[2] Univ Rochester, Sch Med & Dent, Dept Med, Nephrol Div, Rochester, NY USA

来源：

SEMINARS IN NEPHROLOGY | 2019年 / 39卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Renal insufficiency; chronic; acidosis; alkalosis; alkali therapy; kidney disease progression; GLOMERULAR-FILTRATION-RATE; RENAL AMMONIA METABOLISM; LONG-TERM OUTCOMES; URINE ANION GAP; SERUM BICARBONATE; DIETARY ACID; TGF-BETA; CKD; ENDOTHELIN; DECLINE;

D O I：

10.1016/j.semnephrol.2019.04.009

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

A large body of work in animals and human beings supports the hypothesis that metabolic acidosis has a deleterious effect on the progression of kidney disease. Alkali therapy, whether pharmacologically or through dietary intervention, appears to slow CKD progression, but an appropriately powered randomized controlled trial with a low risk of bias is required to reach a more definitive conclusion. Recent work on urinary ammonium excretion has shown that the development of prognostic tools related to acidosis is not straightforward, and that application of urine markers such as ammonium may require more nuance than would be predicted based on our understanding of the pathophysiology. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：406 / 417

页数：12

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