Hypoxia signaling: Challenges and opportunities for cancer therapy

被引：31

作者：

Ivan, Mircea ^{[1
,2
]}

Fishel, Melissa L. ^{[3
,4
]}

Tudoran, Oana M. ^{[5
]}

Pollok, Karen E. ^{[3
]}

Wu, Xue ^{[6
]}

Smith, Paul J. ^{[7
]}

机构：

[1] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA

[2] Indiana Univ Sch Med, Dept Microbiol & Immunol, Indianapolis, IN USA

[3] Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN USA

[4] IU Simon Comprehens Canc Ctr, Dept Pharmacol & Toxicol, Indianapolis, IN USA

[5] Oncol Inst Prof Dr Ion Chiricuta, Cluj Napoca, Cluj, Romania

[6] Ohio State Univ, Columbus, OH USA

[7] Cardiff Univ, Sch Med, Cardiff, Wales

来源：

SEMINARS IN CANCER BIOLOGY | 2022年 / 85卷

关键词：

Hypoxia; HIF1; HIF2; HIF inhibitors; Hypoxia-activated prodrug; SMALL-MOLECULE INHIBITOR; ANTI-ANGIOGENIC THERAPY; DNA TOPOISOMERASE-II; CYTOCHROMES P450 CYP; RENAL-CELL CARCINOMA; INDUCIBLE FACTOR; ACTIVATED PRODRUG; N-OXIDE; HEPATOCELLULAR-CARCINOMA; PROLYL HYDROXYLASE;

D O I：

10.1016/j.semcancer.2021.10.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hypoxia is arguably the first recognized cancer microenvironment hallmark and affects virtually all cellular populations present in tumors. During the past decades the complex adaptive cellular responses to oxygen deprivation have been largely elucidated, raising hope for new anti cancer agents. Despite undeniable preclinical progress, therapeutic targeting of tumor hypoxia is yet to transition from bench to bedside. This review focuses on new pharmacological agents that exploit tumor hypoxia or interfere with hypoxia signaling and discusses strategies to maximize their therapeutic impact.

引用

页码：185 / 195

页数：11

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