Hypoxia signaling: Challenges and opportunities for cancer therapy

被引：31
|
作者：
Ivan, Mircea [1 ,2 ]
Fishel, Melissa L. [3 ,4 ]
Tudoran, Oana M. [5 ]
Pollok, Karen E. [3 ]
Wu, Xue [6 ]
Smith, Paul J. [7 ]
机构：
[1] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA
[2] Indiana Univ Sch Med, Dept Microbiol & Immunol, Indianapolis, IN USA
[3] Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN USA
[4] IU Simon Comprehens Canc Ctr, Dept Pharmacol & Toxicol, Indianapolis, IN USA
[5] Oncol Inst Prof Dr Ion Chiricuta, Cluj Napoca, Cluj, Romania
[6] Ohio State Univ, Columbus, OH USA
[7] Cardiff Univ, Sch Med, Cardiff, Wales
来源：
SEMINARS IN CANCER BIOLOGY | 2022年 / 85卷
关键词：
Hypoxia; HIF1; HIF2; HIF inhibitors; Hypoxia-activated prodrug; SMALL-MOLECULE INHIBITOR; ANTI-ANGIOGENIC THERAPY; DNA TOPOISOMERASE-II; CYTOCHROMES P450 CYP; RENAL-CELL CARCINOMA; INDUCIBLE FACTOR; ACTIVATED PRODRUG; N-OXIDE; HEPATOCELLULAR-CARCINOMA; PROLYL HYDROXYLASE;
D O I：
10.1016/j.semcancer.2021.10.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hypoxia is arguably the first recognized cancer microenvironment hallmark and affects virtually all cellular populations present in tumors. During the past decades the complex adaptive cellular responses to oxygen deprivation have been largely elucidated, raising hope for new anti cancer agents. Despite undeniable preclinical progress, therapeutic targeting of tumor hypoxia is yet to transition from bench to bedside. This review focuses on new pharmacological agents that exploit tumor hypoxia or interfere with hypoxia signaling and discusses strategies to maximize their therapeutic impact.
引用
收藏
页码：185 / 195
页数：11
相关论文
共 50 条
  • [21] Delivery of Nanoconstructs in Cancer Therapy: Challenges and Therapeutic Opportunities
    Saw, Wen Shang
    Anasamy, Theebaa
    Foo, Yiing Yee
    Kwa, Yee Chu
    Kue, Chin Siang
    Yeong, Chai Hong
    Kiew, Lik Voon
    Lee, Hong Boon
    Chung, Lip Yong
    ADVANCED THERAPEUTICS, 2021, 4 (03)
  • [22] Bioinspired microrobots: Opportunities and challenges in targeted cancer therapy
    Singh, Arun Kumar
    Awasthi, Rajendra
    Malviya, Rishabha
    JOURNAL OF CONTROLLED RELEASE, 2023, 354 : 439 - 452
  • [23] Autophagy modulation in cancer therapy: Challenges coexist with opportunities
    Wu, Yongya
    Wang, Aoxue
    Feng, Guotai
    Pan, Xiaoli
    Shuai, Wen
    Yang, Panpan
    Zhang, Jing
    Ouyang, Liang
    Luo, Yi
    Wang, Guan
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 276
  • [24] Opportunities and challenges for TCR mimic antibodies in cancer therapy
    Chang, Aaron Y.
    Gejman, Ron S.
    Bre, Elliott J.
    Oh, Claire Y.
    Mathias, Melissa D.
    Pankov, Dmitry
    Casey, Emily
    Dao, Tao
    Scheinberg, David A.
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2016, 16 (08) : 979 - 987
  • [25] Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications
    Wicki, Andreas
    Witzigmann, Dominik
    Balasubramanian, Vimalkumar
    Huwyler, Joerg
    JOURNAL OF CONTROLLED RELEASE, 2015, 200 : 138 - 157
  • [26] Opportunities and challenges in targeted therapy and immunotherapy for pancreatic cancer
    Cao, Dujuan
    Song, Qianqian
    Li, Junqi
    Jiang, Yuanyuan
    Wang, Zhimin
    Lu, Shuangshuang
    EXPERT REVIEWS IN MOLECULAR MEDICINE, 2021, 23
  • [27] (Nano)platforms in bladder cancer therapy: Challenges and opportunities
    Ashrafizadeh, Milad
    Zarrabi, Ali
    Karimi-Maleh, Hassan
    Taheriazam, Afshin
    Mirzaei, Sepideh
    Hashemi, Mehrdad
    Hushmandi, Kiavash
    Makvandi, Pooyan
    Nazarzadeh Zare, Ehsan
    Sharifi, Esmaeel
    Goel, Arul
    Wang, Lingzhi
    Ren, Jun
    Nuri Ertas, Yavuz
    Kumar, Alan Prem
    Wang, Yuzhuo
    Rabiee, Navid
    Sethi, Gautam
    Ma, Zhaowu
    BIOENGINEERING & TRANSLATIONAL MEDICINE, 2023, 8 (01)
  • [28] Current Challenges and Opportunities of Photodynamic Therapy against Cancer
    In't Veld, Ruben V. Huis V.
    Heuts, Jeroen
    Ma, Sen
    Cruz, Luis J. J.
    Ossendorp, Ferry A. A.
    Jager, Martine J. J.
    PHARMACEUTICS, 2023, 15 (02)
  • [29] Opportunities and challenges in the development of kinase inhibitor therapy for cancer
    Sawyers, CL
    GENES & DEVELOPMENT, 2003, 17 (24) : 2998 - 3010
  • [30] Activating Wnt/β-catenin signaling pathway for disease therapy: Challenges and opportunities
    Huang, Piao
    Yan, Rong
    Zhang, Xue
    Wang, Lei
    Ke, Xisong
    Qu, Yi
    PHARMACOLOGY & THERAPEUTICS, 2019, 196 : 79 - 90
12345