ANCA-associated vasculitis

被引：165

作者：

Yates, Max ^{[1
,2
,3
]}

Watts, Richard ^{[3
,4
]}

机构：

[1] Arthrit Res UK, Norwich, Norfolk, England

[2] Univ East Anglia, Norwich Univ Hosp NHS Fdn Trust, Norwich, Norfolk, England

[3] Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England

[4] Ipswich Hosp, Ipswich, Suffolk, England

来源：

CLINICAL MEDICINE | 2017年 / 17卷 / 01期

基金：

欧盟地平线“2020”;

关键词：

ANCA; diagnosis; rituximab; treatment; vasculitis; ANTIBODY-ASSOCIATED VASCULITIS; (ANCA)-ASSOCIATED VASCULITIS; RANDOMIZED-TRIAL; RITUXIMAB; CYCLOPHOSPHAMIDE; MAINTENANCE; REMISSION; MANAGEMENT; INDUCTION; THERAPY;

D O I：

10.7861/clinmedicine.17-1-60

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The vasculitides are a heterogeneous group of conditions typified by their ability to cause vessel inflammation with or without necrosis. They present with a wide variety of signs and symptoms and, if left untreated, carry a significant burden of mortality and morbidity. The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are three separate conditions granulomatosis with polyangiitis (GPA; formerly known as Wegener's granulomatosis), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA; previously known as Churg-Strauss syndrome). This review examines recent developments in the pathogenesis and treatment of AAV, focusing on developments in treatment following the introduction of rituximab, in particular.

引用

页码：60 / 64

页数：5

共 20 条

[1] SEGMENTAL NECROTIZING GLOMERULONEPHRITIS WITH ANTI-NEUTROPHIL ANTIBODY - POSSIBLE ARBOVIRUS ETIOLOGY [J].

DAVIES, DJ ;

MORAN, JE ;

NIALL, JF ;

RYAN, GB .

BMJ-BRITISH MEDICAL JOURNAL, 1982, 285 (6342) :606-606

[2] Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody-associated vasculitis [J].

de Groot, K ;

Rasmussen, N ;

Bacon, PA ;

Tervaert, JWC ;

Feighery, C ;

Gregorini, G ;

Gross, WL ;

Luqmani, R ;

Jayne, DRW .

ARTHRITIS AND RHEUMATISM, 2005, 52 (08) :2461-2469

[3] Rituximab versus Azathioprine for Maintenance in ANCA-Associated Vasculitis [J].

Guillevin, L. ;

Pagnoux, C. ;

Karras, A. ;

Khouatra, C. ;

Aumaitre, O. ;

Cohen, P. ;

Maurier, F. ;

Decaux, O. ;

Ninet, J. ;

Gobert, P. ;

Quemeneur, T. ;

Blanchard-Delaunay, C. ;

Godmer, P. ;

Puechal, X. ;

Carron, P. -L. ;

Hatron, P. -Y. ;

Limal, N. ;

Hamidou, M. ;

Ducret, M. ;

Daugas, E. ;

Papo, T. ;

Bonnotte, B. ;

Mahr, A. ;

Ravaud, P. ;

Mouthon, L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (19) :1771-1780

[4] Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up [J].

Harper, Lorraine ;

Morgan, Matthew D. ;

Walsh, Michael ;

Hoglund, Peter ;

Westman, Kerstin ;

Flossmann, Oliver ;

Tesar, Vladimir ;

Vanhille, Phillipe ;

de Groot, Kirsten ;

Luqmani, Raashid ;

Felipe Flores-Suarez, Luis ;

Watts, Richard ;

Pusey, Charles ;

Bruchfeld, Annette ;

Rasmussen, Niels ;

Blockmans, Daniel ;

Savage, Caroline O. ;

Jayne, David .

ANNALS OF THE RHEUMATIC DISEASES, 2012, 71 (06) :955-960

[5] EULAR recommendations for conducting clinical studies and/or clinical trials in systemic vasculitis: focus on anti-neutrophil cytoplasm antibody-associated vasculitis [J].

Hellmich, Bernhard ;

Flossmann, Oliver ;

Gross, Wolfgang L. ;

Bacon, Paul ;

Cohen-Tervaert, Jan Willem ;

Guillevin, Loic ;

Jayne, David ;

Mahr, Alfred ;

Merkel, Peter A. ;

Raspe, Heiner ;

Scott, David G. I. ;

Witter, James ;

Yazici, Hasan ;

Luqmani, Raashid A. .

ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (05) :605-617

[6] Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis [J].

Hilhorst, Marc ;

van Paassen, Pieter ;

Tervaert, Jan Willem Cohen .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2015, 26 (10) :2314-2327

[7] A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies [J].

Jayne, D ;

Rasmussen, N ;

Andrassy, K ;

Bacon, P ;

Tervaert, JWC ;

Dadoniene, J ;

Ekstrand, A ;

Gaskin, G ;

Gregorini, G ;

de Groot, K ;

Gross, W ;

Hagen, EC ;

Mirapeix, E ;

Pettersson, E ;

Siegert, C ;

Sinico, A ;

Tesar, V ;

Westman, K ;

Pusey, C .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (01) :36-44

[8] 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides [J].

Jennette, J. C. ;

Falk, R. J. ;

Bacon, P. A. ;

Basu, N. ;

Cid, M. C. ;

Ferrario, F. ;

Flores-Suarez, L. F. ;

Gross, W. L. ;

Guillevin, L. ;

Hagen, E. C. ;

Hoffman, G. S. ;

Jayne, D. R. ;

Kallenberg, C. G. M. ;

Lamprecht, P. ;

Langford, C. A. ;

Luqmani, R. A. ;

Mahr, A. D. ;

Matteson, E. L. ;

Merkel, P. A. ;

Ozen, S. ;

Pusey, C. D. ;

Rasmussen, N. ;

Rees, A. J. ;

Scott, D. G. I. ;

Specks, U. ;

Stone, J. H. ;

Takahashi, K. ;

Watts, R. A. .

ARTHRITIS AND RHEUMATISM, 2013, 65 (01) :1-11

[9] Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis. [J].

Jones, Rachel B. ;

Tervaert, Jan Willem Cohen ;

Hauser, Thomas ;

Luqmani, Raashid ;

Morgan, Matthew D. ;

Peh, Chen Au ;

Savage, Caroline O. ;

Segelmark, Marten ;

Tesar, Vladimir ;

van Paassen, Pieter ;

Walsh, Dorothy ;

Walsh, Michael ;

Westman, Kerstin ;

Jayne, David R. W. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (03) :211-220

[10] A Multicenter Survey of Rituximab Therapy for Refractory Antineutrophil Cytoplasmic Antibody-Associated Vasculitis [J].

Jones, Rachel B. ;

Ferraro, Alastair J. ;

Chaudhry, Afzal N. ;

Brogan, Paul ;

Salama, Alan D. ;

Smith, Kenneth G. C. ;

Savage, Caroline O. S. ;

Jayne, David R. W. .

ARTHRITIS AND RHEUMATISM, 2009, 60 (07) :2156-2168

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