ANCA-associated vasculitis

被引:165
作者
Yates, Max [1 ,2 ,3 ]
Watts, Richard [3 ,4 ]
机构
[1] Arthrit Res UK, Norwich, Norfolk, England
[2] Univ East Anglia, Norwich Univ Hosp NHS Fdn Trust, Norwich, Norfolk, England
[3] Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England
[4] Ipswich Hosp, Ipswich, Suffolk, England
基金
欧盟地平线“2020”;
关键词
ANCA; diagnosis; rituximab; treatment; vasculitis; ANTIBODY-ASSOCIATED VASCULITIS; (ANCA)-ASSOCIATED VASCULITIS; RANDOMIZED-TRIAL; RITUXIMAB; CYCLOPHOSPHAMIDE; MAINTENANCE; REMISSION; MANAGEMENT; INDUCTION; THERAPY;
D O I
10.7861/clinmedicine.17-1-60
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The vasculitides are a heterogeneous group of conditions typified by their ability to cause vessel inflammation with or without necrosis. They present with a wide variety of signs and symptoms and, if left untreated, carry a significant burden of mortality and morbidity. The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are three separate conditions granulomatosis with polyangiitis (GPA; formerly known as Wegener's granulomatosis), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA; previously known as Churg-Strauss syndrome). This review examines recent developments in the pathogenesis and treatment of AAV, focusing on developments in treatment following the introduction of rituximab, in particular.
引用
收藏
页码:60 / 64
页数:5
相关论文
共 20 条
[1]   SEGMENTAL NECROTIZING GLOMERULONEPHRITIS WITH ANTI-NEUTROPHIL ANTIBODY - POSSIBLE ARBOVIRUS ETIOLOGY [J].
DAVIES, DJ ;
MORAN, JE ;
NIALL, JF ;
RYAN, GB .
BMJ-BRITISH MEDICAL JOURNAL, 1982, 285 (6342) :606-606
[2]   Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody-associated vasculitis [J].
de Groot, K ;
Rasmussen, N ;
Bacon, PA ;
Tervaert, JWC ;
Feighery, C ;
Gregorini, G ;
Gross, WL ;
Luqmani, R ;
Jayne, DRW .
ARTHRITIS AND RHEUMATISM, 2005, 52 (08) :2461-2469
[3]   Rituximab versus Azathioprine for Maintenance in ANCA-Associated Vasculitis [J].
Guillevin, L. ;
Pagnoux, C. ;
Karras, A. ;
Khouatra, C. ;
Aumaitre, O. ;
Cohen, P. ;
Maurier, F. ;
Decaux, O. ;
Ninet, J. ;
Gobert, P. ;
Quemeneur, T. ;
Blanchard-Delaunay, C. ;
Godmer, P. ;
Puechal, X. ;
Carron, P. -L. ;
Hatron, P. -Y. ;
Limal, N. ;
Hamidou, M. ;
Ducret, M. ;
Daugas, E. ;
Papo, T. ;
Bonnotte, B. ;
Mahr, A. ;
Ravaud, P. ;
Mouthon, L. .
NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (19) :1771-1780
[4]   Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up [J].
Harper, Lorraine ;
Morgan, Matthew D. ;
Walsh, Michael ;
Hoglund, Peter ;
Westman, Kerstin ;
Flossmann, Oliver ;
Tesar, Vladimir ;
Vanhille, Phillipe ;
de Groot, Kirsten ;
Luqmani, Raashid ;
Felipe Flores-Suarez, Luis ;
Watts, Richard ;
Pusey, Charles ;
Bruchfeld, Annette ;
Rasmussen, Niels ;
Blockmans, Daniel ;
Savage, Caroline O. ;
Jayne, David .
ANNALS OF THE RHEUMATIC DISEASES, 2012, 71 (06) :955-960
[5]   EULAR recommendations for conducting clinical studies and/or clinical trials in systemic vasculitis: focus on anti-neutrophil cytoplasm antibody-associated vasculitis [J].
Hellmich, Bernhard ;
Flossmann, Oliver ;
Gross, Wolfgang L. ;
Bacon, Paul ;
Cohen-Tervaert, Jan Willem ;
Guillevin, Loic ;
Jayne, David ;
Mahr, Alfred ;
Merkel, Peter A. ;
Raspe, Heiner ;
Scott, David G. I. ;
Witter, James ;
Yazici, Hasan ;
Luqmani, Raashid A. .
ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (05) :605-617
[6]   Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis [J].
Hilhorst, Marc ;
van Paassen, Pieter ;
Tervaert, Jan Willem Cohen .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2015, 26 (10) :2314-2327
[7]   A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies [J].
Jayne, D ;
Rasmussen, N ;
Andrassy, K ;
Bacon, P ;
Tervaert, JWC ;
Dadoniene, J ;
Ekstrand, A ;
Gaskin, G ;
Gregorini, G ;
de Groot, K ;
Gross, W ;
Hagen, EC ;
Mirapeix, E ;
Pettersson, E ;
Siegert, C ;
Sinico, A ;
Tesar, V ;
Westman, K ;
Pusey, C .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (01) :36-44
[8]   2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides [J].
Jennette, J. C. ;
Falk, R. J. ;
Bacon, P. A. ;
Basu, N. ;
Cid, M. C. ;
Ferrario, F. ;
Flores-Suarez, L. F. ;
Gross, W. L. ;
Guillevin, L. ;
Hagen, E. C. ;
Hoffman, G. S. ;
Jayne, D. R. ;
Kallenberg, C. G. M. ;
Lamprecht, P. ;
Langford, C. A. ;
Luqmani, R. A. ;
Mahr, A. D. ;
Matteson, E. L. ;
Merkel, P. A. ;
Ozen, S. ;
Pusey, C. D. ;
Rasmussen, N. ;
Rees, A. J. ;
Scott, D. G. I. ;
Specks, U. ;
Stone, J. H. ;
Takahashi, K. ;
Watts, R. A. .
ARTHRITIS AND RHEUMATISM, 2013, 65 (01) :1-11
[9]   Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis. [J].
Jones, Rachel B. ;
Tervaert, Jan Willem Cohen ;
Hauser, Thomas ;
Luqmani, Raashid ;
Morgan, Matthew D. ;
Peh, Chen Au ;
Savage, Caroline O. ;
Segelmark, Marten ;
Tesar, Vladimir ;
van Paassen, Pieter ;
Walsh, Dorothy ;
Walsh, Michael ;
Westman, Kerstin ;
Jayne, David R. W. .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (03) :211-220
[10]   A Multicenter Survey of Rituximab Therapy for Refractory Antineutrophil Cytoplasmic Antibody-Associated Vasculitis [J].
Jones, Rachel B. ;
Ferraro, Alastair J. ;
Chaudhry, Afzal N. ;
Brogan, Paul ;
Salama, Alan D. ;
Smith, Kenneth G. C. ;
Savage, Caroline O. S. ;
Jayne, David R. W. .
ARTHRITIS AND RHEUMATISM, 2009, 60 (07) :2156-2168