p-Toluenesulfonic Acid Catalyzed One-Pot Synthesis of 4H-Pyrido[1,2-a]pyrimidin-4-one Derivatives

被引：7

作者：

Liu, Wenjie ^{[1
]}

Wang, Shaohua ^{[1
]}

Zhan, Haiying ^{[1
]}

Li, Mingshan ^{[1
]}

机构：

[1] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Guangzhou 510006, Guangdong, Peoples R China

来源：

SYNLETT | 2014年 / 25卷 / 10期

基金：

中国国家自然科学基金;

关键词：

metal-free; 4H-pyrido[1,2-a]pyrimidin-4-ones; PTSA; 2-aminopyridine; multicomponent reactions; EFFLUX PUMP INHIBITORS; MULTICOMPONENT REACTION; PSEUDOMONAS-AERUGINOSA; 3-COMPONENT REACTION; EXTENDED-RELEASE; 2-AMINOPYRIDINES; PALIPERIDONE; ANALOGS;

D O I：

10.1055/s-0033-1339012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel one-pot protocol has been developed for the construction of alkenylated 4H-pyrido[1,2-a]pyrimidin-4-one derivatives from 2-aminopyridine in the presence of PTSA. The present approach opens a new way for the formation of C-C and C-N bonds under mild conditions.

引用

页码：1478 / 1481

页数：4

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