Anti-inflammatory effects and structure elucidation of two new compounds from Astragalus membranaceus (Fisch) Bge. var. mongholicus (Bge) Hsiao

被引：10

作者：

Wang Qing-Hu ^{[1
]}

Han Na-Ren-Chao-Ke-Tu ^{[1
]}

Dai Na-Yin-Tai ^{[1
]}

Wang Xiu-Lan ^{[1
]}

Ao Wu-Li-Ji ^{[1
]}

机构：

[1] Inner Mongolia Univ Nationalities, Coll Tradit Mongolian Med, Tongliao 028000, Inner Mongolia, Peoples R China

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2014年 / 1074卷

关键词：

Astragalus membranaceus (Fisch) Bge. var. mongholicus (Bge) Hsiao; 1-hydroxy-5-methylolbenzol-2-O-beta-D-glucoside; (3R, 4R)-4,7-hydroxy-2 ',3 '-dimethoxyisoflavane-4 '-O-beta-D-glucoside; Spectroscopic methods; Anti-inflammatory;

D O I：

10.1016/j.molstruc.2014.06.020

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Phytochemical study of the ethanol extract of Astragalus membranaceus (Fisch) Bge. var. mongholicus (Bge) Hsiao resulted to the isolation of two new compounds, 1-hydroxy-5-methylolbenzol-2-O-beta-D-glucoside (1) and (3R, 4R)-4,7-hydroxy-2',3'-dimethoxyisoflavane-4'-O-beta-D-glucoside (2). The structure of the isolated compounds were elucidated on the basis of the spectroscopic methods including UV, IR, ESI-MS, 1D NMR and 2D NMR techniques, and by comparison with those reported in the literature. The new compounds were investigated for its effect against inflammation induced by egg-albumin and carrageenan in rats. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：284 / 288

页数：5

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