Survival of Oral Cancer Patients in Different Ethnicities

被引：27

作者：

Ghani, Wan Maria Nabillah ^{[1
]}

Ramanathan, Anand ^{[2
]}

Prime, Stephen Stewart ^{[3
]}

Yang, Yi-Hsin ^{[4
]}

Razak, Ishak Abdul ^{[5
]}

Rahman, Zainal Ariff Abdul ^{[2
]}

Abraham, Mannil Thomas ^{[6
]}

Mustafa, Wan Mahadzir Wan ^{[5
]}

Tay, Keng Kiong ^{[6
]}

Kallarakkal, Thomas George ^{[2
]}

Doss, Jennifer Geraldine ^{[1
,7
]}

Cheong, Sok Ching ^{[8
]}

Bustam, Anita Zarina ^{[9
]}

Zain, Rosnah Binti ^{[1
,5
]}

机构：

[1] Univ Malaya, Fac Dent, OCRCC, Level 7,Dent Specialist & Res Tower, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Fac Dent, Dept Oromaxillofacial Surg & Med Sci, Kuala Lumpur, Malaysia

[3] Queen Mary Univ London, Ctr Clin & Diagnost Oral Sci, Inst Dent, Barts & London Sch Dent, London, England

[4] Kaohsiung Med Univ, Sch Pharm, Kaohsiung, Taiwan

[5] MAHSA Univ, Fac Dent, Bandar Saujana Putra, Malaysia

[6] Minist Hlth, Oral Hlth Div, Putrajaya, Malaysia

[7] Univ Malaya, Fac Dent, Dept Community Oral Hlth & Clin Prevent, Kuala Lumpur, Malaysia

[8] Canc Res Malaysia, Oral Canc Res Team, Subang Jaya, Malaysia

[9] Univ Malaya, Fac Med, Clin Oncol Unit, Kuala Lumpur, Malaysia

来源：

CANCER INVESTIGATION | 2019年 / 37卷 / 07期

关键词：

Head and neck cancer; prognostic studies; ethnicity; mouth neoplasm; SQUAMOUS-CELL CARCINOMA; INDEPENDENT PROGNOSTIC-FACTORS; BETEL-QUID; MUTATIONAL LANDSCAPE; RACIAL-DIFFERENCES; ALCOHOL-DRINKING; TOBACCO SMOKING; CAVITY CANCER; HEAD; REVEALS;

D O I：

10.1080/07357907.2019.1635614

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Previous studies found that ethnicity influences oral cancer patients' survival; however, most studies were limited to certain ethnic groups particularly from the West, thus of limited relevance to Asians where the disease is most prevalent. We investigated the relationship between ethnicity and patient survival in multi-racial Malaysia. 5-year survival rate was 40.9%. No statistically significant difference was observed in survival between Malays, Chinese, Indians and Indigenous peoples (45.7%, 44.0%, 41.3%, 27.7% respectively). Increased tumor size, lymph node involvement and advanced tumor were predictive of poor survival. We conclude that ethnicity has no effect on survival or its prognostic indicators.

引用

页码：275 / 287

页数：13

共 46 条

[1] Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1 [J].

Agrawal, Nishant ;

Frederick, Mitchell J. ;

Pickering, Curtis R. ;

Bettegowda, Chetan ;

Chang, Kyle ;

Li, Ryan J. ;

Fakhry, Carole ;

Xie, Tong-Xin ;

Zhang, Jiexin ;

Wang, Jing ;

Zhang, Nianxiang ;

El-Naggar, Adel K. ;

Jasser, Samar A. ;

Weinstein, John N. ;

Trevino, Lisa ;

Drummond, Jennifer A. ;

Muzny, Donna M. ;

Wu, Yuanqing ;

Wood, Laura D. ;

Hruban, Ralph H. ;

Westra, William H. ;

Koch, Wayne M. ;

Califano, Joseph A. ;

Gibbs, Richard A. ;

Sidransky, David ;

Vogelstein, Bert ;

Velculescu, Victor E. ;

Papadopoulos, Nickolas ;

Wheeler, David A. ;

Kinzler, Kenneth W. ;

Myers, Jeffrey N. .

SCIENCE, 2011, 333 (6046) :1154-1157

[2] Clinical and histopathologic independent prognostic factors in oral squamous cell carcinoma: A retrospective study of 334 cases [J].

Arduino, Paolo G. ;

Carrozzo, Marco ;

Chiecchio, Andrea ;

Broccoletti, Roberto ;

Tirone, Federico ;

Borra, Eleonora ;

Bertolusso, Giorgio ;

Gandolfo, Sergio .

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2008, 66 (08) :1570-1579

[3]

Aruna DS, 2011, ASIAN PAC J CANCER P, V12, P1561

[4] Gender- and ethnicity-specific survival trends of oral cavity and oropharyngeal cancers in British Columbia [J].

Auluck, Ajit ;

Hislop, Greg ;

Bajdik, Chris ;

Hay, John ;

Bottorff, Joan L. ;

Zhang, Lewei ;

Rosin, Miriam P. .

CANCER CAUSES & CONTROL, 2012, 23 (12) :1899-1909

[5]

Azizah A M., 2016, Malaysian national cancer registry report 2007-2011. Malaysia cancer statistics, data and figure

[6] Oral cancer in Southern India:: The influence of smoking, drinking, paan-chewing and oral hygiene [J].

Balaram, P ;

Sridhar, H ;

Rajkumar, T ;

Vaccarella, S ;

Herrero, R ;

Nandakumar, A ;

Ravichandran, K ;

Ramdas, K ;

Sankaranarayanan, R ;

Gajalakshmi, V ;

Muñoz, N ;

Franceschi, S .

INTERNATIONAL JOURNAL OF CANCER, 2002, 98 (03) :440-445

[7] Tongue cancer: Is there a difference in survival compared with other subsites in the oral cavity? [J].

Bell, R. Bryan ;

Kademani, Deepak ;

Homer, Louis ;

Dierks, Eric J. ;

Potter, Bryce E. .

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2007, 65 (02) :229-236

[8] Prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan [J].

Chen, Ping-Ho ;

Shieh, Tien-Yu ;

Ho, Pei-Shan ;

Tsai, Chi-Cheng ;

Yang, Yi-Hsin ;

Lin, Ying-Chu ;

Ko, Min-Shan ;

Tsai, Pei-Chien ;

Chiang, Shang-Lun ;

Tu, Hung-Pin ;

Ko, Ying-Chin .

BMC CANCER, 2007, 7 (1)

[9] Primary oral squamous cell carcinoma: an analysis of 703 cases in southern Taiwan [J].

Chen, YK ;

Huang, HC ;

Lin, LM ;

Lin, CC .

ORAL ONCOLOGY, 1999, 35 (02) :173-179

[10] Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure [J].

Cheong, S. C. ;

Chandramouli, G. V. R. ;

Saleh, A. ;

Zain, R. B. ;

Lau, S. H. ;

Sivakumaren, S. ;

Pathmanathan, R. ;

Prime, S. S. ;

Teo, S. H. ;

Patel, V. ;

Gutkind, J. S. .

ORAL ONCOLOGY, 2009, 45 (08) :712-719

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