Digitoxin Analogues with Improved Anticytomegalovirus Activity

被引：39

作者：

Cai, Hongyi ^{[1
]}

Wang, Hua-Yu L. ^{[3
]}

Venkatadri, Rajkumar ^{[1
]}

Fu, De-Xue ^{[1
]}

Forman, Michael ^{[2
]}

Bajaj, Sumit O. ^{[3
]}

Li, Hongyan ^{[3
]}

O'Doherty, George A. ^{[3
]}

Arav-Boger, Ravit ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21287 USA

[2] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21287 USA

[3] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2014年 / 5卷 / 04期

基金：

美国国家科学基金会;

关键词：

Cardiac glycosides; digitoxin analogues; cytomegalovirus; virus inhibition; CARDIAC-GLYCOSIDES; CANCER; DIGOXIN; THERAPY; OLIGOSACCHARIDES; PROSCILLARIDIN; NA; K-ATPASE; INHIBITION; OUABAIN; GROWTH;

D O I：

10.1021/ml400529q

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cardiac glycosides are potent inhibitors of cancer cell growth and possess antiviral activities at nanomolar concentrations. In this study we evaluated the anticytomegalovirus (CMV) activity of digitoxin and several of its analogues. We show that sugar type and sugar length attached to the steroid core structure affects its anticytomegalovirus activity. Structure activity relationship (SAR) studies identified the L-sugar containing cardiac glycosides as having improved anti-CMV activity and may lead to better understanding of how these compounds inhibit CMV replication.

引用

页码：395 / 399

页数：5

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