Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline

被引：195

作者：

Da Cunha, Violette ^{[1
,2
,3
]}

Davies, Mark R. ^{[4
,5
]}

Douarre, Pierre-Emmanuel ^{[1
,2
]}

Rosinski-Chupin, Isabelle ^{[1
,2
]}

Margarit, Immaculada ^{[6
]}

Spinali, Sebastien ^{[7
]}

Perkins, Tim ^{[6
]}

Lechat, Pierre ^{[3
]}

Dmytruk, Nicolas ^{[7
]}

Sauvage, Elisabeth ^{[1
,2
]}

Ma, Laurence ^{[8
]}

Romi, Benedetta ^{[6
]}

Tichit, Magali ^{[8
]}

Lopez-Sanchez, Maria-Jose ^{[1
,2
]}

Descorps-Declere, Stephane ^{[3
]}

Souche, Erika ^{[3
]}

Buchrieser, Carmen ^{[2
,9
]}

Trieu-Cuot, Patrick ^{[1
,10
]}

Moszer, Ivan ^{[3
]}

Clermont, Dominique ^{[11
]}

Maione, Domenico ^{[6
]}

Bouchier, Christiane ^{[8
]}

McMillan, David J. ^{[12
,13
]}

Parkhill, Julian ^{[4
]}

Telford, John L. ^{[6
]}

Dougan, Gordan ^{[4
]}

Walker, Mark J. ^{[5
]}

Holden, Matthew T. G. ^{[4
]}

Poyart, Claire ^{[1
,7
,14
,15
]}

Glaser, Philippe ^{[1
,2
,3
]}

Melin, Pierette ^{[16
]}

Decheva, Antoaneta ^{[17
]}

Petrunov, Bogdan ^{[17
]}

Kriz, Paula ^{[18
]}

Berner, Reinhard ^{[19
]}

Buechele, Anna ^{[19
]}

Hufnagel, Markus ^{[19
]}

Kunze, Mirjam ^{[19
]}

Creti, Roberta ^{[20
]}

Baldassari, Lucilia ^{[20
]}

Orefici, Graziella ^{[20
]}

Berardi, Alberto ^{[21
]}

Rodriguez Granger, Javier ^{[22
]}

De La Rosa Fraile, Manuel ^{[22
]}

Afshar, Baharak ^{[23
]}

Efstratiou, Androulla ^{[23
]}

机构：

[1] Inst Pasteur, Unite Biol Bacteries Pathogenes Gram Positif, F-75015 Paris, France

[2] CNRS, UMR3525, F-75015 Paris, France

[3] Inst Pasteur, F-75015 Paris, France

[4] Wellcome Trust Sanger Inst, Cambridge CB10 15A, England

[5] Univ Queensland, Sch Chem & Mol Biosci, Australian Infect Dis Res Ctr, Brisbane, Qld 4072, Australia

[6] Novartis Vaccines & Diagnost, I-53100 Siena, Italy

[7] Hop Univ, CNRS, Paris Ctr Cochin Hotel Dieu Broca, F-75014 Paris, France

[8] Inst Pasteur Genom Platform, F-75015 Paris, France

[9] Inst Pasteur, F-75015 Paris, France

[10] CNRS, ERL3526, F-75015 Paris, France

[11] Inst Pasteur, CIP, F-75015 Paris, France

[12] QIMR Berghofer Med Res Inst, Brisbane, Qld 7006, Australia

[13] Univ Sunshine Coast, Sippy Downs, Qld 4556, Australia

[14] Univ Sorbonne Paris Descartes, Inst Cochin, F-75014 Paris, France

[15] INSERM, U1016, F-75014 Paris, France

[16] Univ Liege, Natl Reference Ctr Grp B Streptococci, B-4000 Liege, Belgium

[17] Natl Ctr Infect & Parasit Dis, BG-1504 Sofia, Bulgaria

[18] Natl Inst Publ Hlth, Prague 10042, Czech Republic

[19] Univ Hosp Freiburg, D-79106 Freiburg, Germany

[20] Ist Super Sanita, I-00161 Rome, Italy

[21] Azienda Ospedaliero Univ Policlinico, I-41124 Modena, Italy

[22] Hosp Univ Virgen Nieves, E-18014 Granada, Spain

[23] Hlth Protect Agcy Ctr Infect, London NW9 5EQ, England

来源：

NATURE COMMUNICATIONS | 2014年 / 5卷

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

ANTIMICROBIAL RESISTANCE; ANTIBIOTIC-RESISTANCE; POPULATION-STRUCTURE; MOLECULAR EPIDEMIOLOGY; GENETIC ELEMENTS; GENOME SEQUENCE; SEROTYPES; BOVINE; EVOLUTION; ALIGNMENT;

D O I：

10.1038/ncomms5544

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Streptococcus agalactiae (Group B Streptococcus, GBS) is a commensal of the digestive and genitourinary tracts of humans that emerged as the leading cause of bacterial neonatal infections in Europe and North America during the 1960s. Due to the lack of epidemiological and genomic data, the reasons for this emergence are unknown. Here we show by comparative genome analysis and phylogenetic reconstruction of 229 isolates that the rise of human GBS infections corresponds to the selection and worldwide dissemination of only a few clones. The parallel expansion of the clones is preceded by the insertion of integrative and conjugative elements conferring tetracycline resistance (TcR). Thus, we propose that the use of tetracycline from 1948 onwards led in humans to the complete replacement of a diverse GBS population by only few TcR clones particularly well adapted to their host, causing the observed emergence of GBS diseases in neonates.

引用

页数：11

共 58 条

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