Regioselective synthesis of 3,4,5-trisubstituted 2-aminofurans

被引：15

作者：

Thi Ngoc Tram Huynh ^{[1
,2
]}

Retailleau, Pascal ^{[3
]}

Denhez, Clement ^{[1
]}

Kim Phi Phung Nguyen ^{[2
]}

Guillaume, Dom ^{[1
]}

机构：

[1] Univ Reims, UFR Pharm, CNRS, ICMR,UMR7312, F-51096 Reims, France

[2] Natl Univ Ho Chi Minh City, Univ Sci, Dept Organ Chem, Ho Chi Minh City 748355, Vietnam

[3] CNRS, Inst Chim Subst Nat, UPR2301, F-91190 Gif Sur Yvette, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 28期

关键词：

ONE-POT SYNTHESIS; POLYSUBSTITUTED FURANS; 3-COMPONENT SYNTHESIS; DERIVATIVES; CONSTRUCTION; ISOCYANIDES; CYCLIZATION; MOLECULES; ALDEHYDES; SYSTEMS;

D O I：

10.1039/c4ob01037j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three series of methyl 5-substituted 2-aminofuran-4-keto-3-carboxylates have been prepared following a multicomponent reaction strategy by the addition of an isocyanide to 4-oxo-2-butynoate in the presence of an aldehyde. The cycloaddition regioselectivity is generally high (>95%) but decreases when an electron-rich substituent is located at the butynoate 4-position.

引用

页码：5098 / 5101

页数：4

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