Asymmetric total synthesis of fluvirucinine A1

被引：0

作者：

Suh, YG ^{[1
]}

Kim, SA ^{[1
]}

Jung, JK ^{[1
]}

Shin, DY ^{[1
]}

Min, KH ^{[1
]}

Koo, BA ^{[1
]}

Kim, HS ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Kwanak Gu, Seoul 151742, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 1999年 / 38卷 / 23期

关键词：

alkaloids; antiviral agents; natural products; rearrangements; total synthesis;

D O I：

10.1002/(SICI)1521-3773(19991203)38:23<3545::AID-ANIE3545>3.0.CO;2-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Diastereoselective vinyl addition to an amide carbonyl group and amide enolate induced aza-Claisen rearrangement are the key steps in the first asymmetric total synthesis of fluvirucinine A1 (1), the aglycon of fluvirucin A1. Fluvirucins are a class of macrolactam antibiotics produced by actinomycete strains that show promising biological properties.

引用

页码：3545 / 3547

页数：3

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