CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension

被引：42
作者：
Kassan, Modar [1 ]
Wecker, Andrea [1 ]
Kadowitz, Philip [2 ]
Trebak, Mohamed [3 ]
Matrougui, Khalid [1 ]
机构：
[1] Eastern Virginia Med Sch, Dept Physiol Sci, Norfolk, VA 23501 USA
[2] Tulane Univ, Dept Pharmacol, New Orleans, LA 70118 USA
[3] SUNY Albany, Coll Nanoscale Sci & Engn, Albany, NY 12222 USA
来源：
JOURNAL OF HYPERTENSION | 2013年 / 31卷 / 10期
基金：
美国国家卫生研究院;
关键词：
hypertension; regulatory T cell; vascular dysfunction; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; NADPH OXIDASE; EXPRESSION; KIDNEY; ALPHA; INFLAMMATION; MECHANISMS; GENERATION; FOXP3;
D O I：
10.1097/HJH.0b013e328362feb7
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Endothelial dysfunction plays a key role in the development and progression of cardiovascular disease. In patients with hypertension, endothelial dysfunction is characterized by a decrease of vasodilator factors release. Recent evidence highlights the involvement of regulatory T cell in the cardiovascular physiology and pathology. An increasing body of data suggest that an imbalance in the immune system triggers inflammation and compromises the cardiovascular homeostasis. In this mini-review, we will highlight the role of immune regulatory T cells in hypertension-induced vascular dysfunction.
引用
收藏
页码：1939 / 1943
页数：5
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