CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension

被引：42

作者：

Kassan, Modar ^{[1
]}

Wecker, Andrea ^{[1
]}

Kadowitz, Philip ^{[2
]}

Trebak, Mohamed ^{[3
]}

Matrougui, Khalid ^{[1
]}

机构：

[1] Eastern Virginia Med Sch, Dept Physiol Sci, Norfolk, VA 23501 USA

[2] Tulane Univ, Dept Pharmacol, New Orleans, LA 70118 USA

[3] SUNY Albany, Coll Nanoscale Sci & Engn, Albany, NY 12222 USA

来源：

JOURNAL OF HYPERTENSION | 2013年 / 31卷 / 10期

基金：

美国国家卫生研究院;

关键词：

hypertension; regulatory T cell; vascular dysfunction; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; NADPH OXIDASE; EXPRESSION; KIDNEY; ALPHA; INFLAMMATION; MECHANISMS; GENERATION; FOXP3;

D O I：

10.1097/HJH.0b013e328362feb7

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Endothelial dysfunction plays a key role in the development and progression of cardiovascular disease. In patients with hypertension, endothelial dysfunction is characterized by a decrease of vasodilator factors release. Recent evidence highlights the involvement of regulatory T cell in the cardiovascular physiology and pathology. An increasing body of data suggest that an imbalance in the immune system triggers inflammation and compromises the cardiovascular homeostasis. In this mini-review, we will highlight the role of immune regulatory T cells in hypertension-induced vascular dysfunction.

引用

页码：1939 / 1943

页数：5

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