PI 3-kinases and PTEN: How opposites chemoattract

被引：111
作者：
Parent, CA
机构：
[1] NCI, Cellular & Mol Biol Lab, NIH, Bethesda, MD 20892 USA
[2] Natl Inst Gen Med Sci, PRAT Res Fellowship Program, NIH, Bethesda, MD 20892 USA
来源：
CELL | 2002年 / 109卷 / 05期
关键词：
D O I：
10.1016/S0092-8674(02)00765-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Phosphatidylinositol lipids, such as PI(4,5)P-2 and PI(3,4,5)P-3, are key mediators in diverse intracellular signaling pathways. Two recent reports examine how the metabolism of these lipids by phosphatidylinositol 3-kinases and the PTEN 3-phosphoinositide phosphatase may coordinate G protein coupled signaling pathways during eukaryotic chemotaxis.
引用
收藏
页码：541 / 544
页数：4
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