miR-30c-2-3p and miR-30a-3p: New Pieces of the Jigsaw Puzzle in HIF2α Regulation

被引：11

作者：

Moch, Holger ^{[1
]}

Lukamowicz-Rajska, Magdalena ^{[1
]}

机构：

[1] Univ Zurich Hosp, Inst Surg Pathol, CH-8091 Zurich, Switzerland

来源：

CANCER DISCOVERY | 2014年 / 4卷 / 01期

关键词：

CELL RENAL-CARCINOMA; KIDNEY CANCER; IDENTIFICATION;

D O I：

10.1158/2159-8290.CD-13-0897

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clear cell renal cell carcinoma (ccRCC), the most frequent subtype of renal cell cancer, is characterized by mutation of the von Hippel-Lindau (VHL) tumor suppressor gene, which results in stabilization of hypoxia-inducible factor (HIF) a proteins. In this issue of Cancer Discovery, Mathew and colleagues report that miR-30c-2-3p and miR-30a-3p downregulation in ccRCC promotes increased expression of HIF2α. © 2014 AACR.

引用

页码：22 / 24

页数：3

共 10 条

[1] Role of hypoxia-inducible factor (HIF)-1α-versus HIF-2α in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-1, or loss of von Hippel-Lindau function:: Implications for targeting the HIF pathway [J].

Carroll, Veronica A. ;

Ashcroft, Margaret .

CANCER RESEARCH, 2006, 66 (12) :6264-6270

[2] HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma [J].

Gordan, John D. ;

Lal, Priti ;

Dondeti, Vijay R. ;

Letrero, Richard ;

Parekh, Krishna N. ;

Oquendo, C. Elisa ;

Greenberg, Roger A. ;

Flaherty, Keith T. ;

Rathmell, W. Kimryn ;

Keith, Brian ;

Simon, M. Celeste ;

Nathanson, Katherine L. .

CANCER CELL, 2008, 14 (06) :435-446

[3]

Huang J, 2013, CANC SCI

[4] Identification of a MicroRNA Panel for Clear-cell Kidney Cancer [J].

Juan, David ;

Alexe, Gabriela ;

Antes, Travis ;

Liu, Huiqing ;

Madabhushi, Anant ;

Delisi, Charles ;

Ganesan, Shridhar ;

Bhanot, Gyan ;

Liou, Louis S. .

UROLOGY, 2010, 75 (04) :835-841

[5] Restricted Expression of miR-30c-2-3p and miR-30a-3p in Clear Cell Renal Cell Carcinomas Enhances HIF2α Activity [J].

Mathew, Lijoy K. ;

Lee, Samuel S. ;

Skuli, Nicolas ;

Rao, Shilpa ;

Keith, Brian ;

Nathanson, Katherine L. ;

Lal, Priti ;

Simon, M. Celeste .

CANCER DISCOVERY, 2014, 4 (01) :53-60

[6] An overview of renal cell cancer: Pathology and genetics [J].

Moch, Holger .

SEMINARS IN CANCER BIOLOGY, 2013, 23 (01) :3-9

[7] The VHL-dependent regulation of microRNAs in renal cancer [J].

Neal, Calida S. ;

Michael, Michael Z. ;

Rawlings, Lesley H. ;

Van der Hoek, Mark B. ;

Gleadle, Jonathan M. .

BMC MEDICINE, 2010, 8

[8] The VHL/HIF axis in clear cell renal carcinoma [J].

Shen, Chuan ;

Kaelin, William G., Jr. .

SEMINARS IN CANCER BIOLOGY, 2013, 23 (01) :18-25

[9] Genetic and Functional Studies Implicate HIF1α as a 14q Kidney Cancer Suppressor Gene [J].

Shen, Chuan ;

Beroukhim, Rameen ;

Schumacher, Steven E. ;

Zhou, Jing ;

Chang, Michelle ;

Signoretti, Sabina ;

Kaelin, William G., Jr. .

CANCER DISCOVERY, 2011, 1 (03) :222-235

[10] miRNA Profiling for Clear Cell Renal Cell Carcinoma: Biomarker Discovery and Identification of Potential Controls and Consequences of miRNA Dysregulation [J].

White, Nicole M. A. ;

Bao, Tian Tian ;

Grigull, Joerg ;

Youssef, Youssef M. ;

Girgis, Andrew ;

Diamandis, Maria ;

Fatoohi, Eman ;

Metias, Maged ;

Honey, R. John ;

Stewart, Robert ;

Pace, Kenneth T. ;

Bjarnason, Georg A. ;

Yousef, George M. .

JOURNAL OF UROLOGY, 2011, 186 (03) :1077-1083

← 1 →