Preclinical characterization of ALG-031048, a novel STING agonist with potent anti-tumor activity in mice

被引：7
作者：
Jekle, Andreas [1 ]
Thatikonda, Santosh [1 ]
Stevens, Sarah [1 ]
Williams, Caroline [1 ]
Kinkade, April [1 ]
Ren, Suping [1 ]
Jaisinghani, Ruchika [1 ]
Zhang, Qingling [1 ]
Misner, Dinah [1 ]
Stoycheva, Antitsa [1 ]
Deval, Jerome [1 ]
Mukherjee, Sucheta [1 ]
Gonzalvez, Francois [2 ]
Chanda, Sushmita [1 ]
Smith, David B. [1 ]
Symons, Julian A. [1 ]
Blatt, Lawrence M. [1 ]
Beigelman, Leonid [1 ]
机构：
[1] Aligos Therapeut, San Francisco, CA USA
[2] Aligos Belgium, Leuven, Belgium
来源：
CANCER RESEARCH | 2020年 / 80卷 / 16期
关键词：
D O I：
10.1158/1538-7445.AM2020-4520
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
4520
引用
收藏
页数：2
相关论文
共 50 条
  • [31] STING activation in the tumor microenvironment with a synthetic human STING-activating cyclic dinucleotide leads to potent anti-tumor immunity
    Glickman, Laura Hix
    Kanne, David B.
    Kasibhatla, Shailaja
    Li, Jie
    Pferdekamper, AnneMarie Culazzo
    Gauthier, Kelsey Sivick
    Deng, Weiwen
    Desbien, Anthony L.
    Katibah, George E.
    Leong, Justin J.
    Sung, Leonard
    Metchette, Ken
    Ndubaku, Chudi
    Zheng, Lianxing
    Cho, Charles
    Feng, Yan
    McKenna, Jeffrey M.
    Tallarico, John A.
    Bender, Steven L.
    Dubensky, Thomas W.
    McWhirter, Sarah M.
    CANCER RESEARCH, 2016, 76
  • [32] Discovery of a novel HDM2 inhibitor with potent in vivo anti-tumor activity
    Wang, Yaolin
    Lipari, Philip
    Mirza, Asra
    Lin, Yinghui
    Zhang, Rumin
    Bogen, Stephane
    Bogen, Stephane
    Ma, Yao
    Hicklin, Daniel J.
    Seidel-Dugan, Cynthia
    Liu, Suxing
    Wang, Xiaoying
    Doll, Ronald
    Shipps, Gerald
    Bishop, Walter Robert
    CANCER RESEARCH, 2012, 72
  • [33] TOXICOLOGY AND ANTI-TUMOR ACTIVITY OF TUFTSIN IN MICE
    CATANE, R
    SCHLANGER, S
    GOTTLIEB, P
    HALPERN, J
    TREVES, AJ
    FUKS, Z
    FRIDKIN, M
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1981, 22 (MAR): : 371 - 371
  • [34] Intravenous administration of the small molecule STING agonist CRD5500 elicits potent anti-tumor immune responses in cold tumors
    Banerjee, Monali
    Basu, Sourav
    Middya, Sandip
    Shrivastava, Ritesh
    Middya, Anindita
    Ghosh, Rajib
    Mansuri, Rubeena R.
    Mane, Nagaswamy
    Soram, Thanilsana
    Yadav, Dharmendra
    Chakraborty, Debjani
    Singh, Anuj
    Pryde, David C.
    Puniya, Kavita
    Rawat, Nidhi
    Surya, Arjun
    CANCER RESEARCH, 2022, 82 (12)
  • [35] A novel STING agonist with systemic and durable anti-tumour activity
    Wang, Xiyuan
    Shen, Ancheng
    Zhang, Yan
    Chen, Xiaoxu
    Ding, Jian
    Zhang, Ao
    Geng, Meiyu
    Ding, Chunyong
    Xie, Zuoquan
    CLINICAL AND TRANSLATIONAL DISCOVERY, 2023, 3 (05):
  • [36] CC-1065 (NSC-298223), A POTENT NEW ANTI-TUMOR AGENT - IMPROVED PRODUCTION AND ISOLATION, CHARACTERIZATION AND ANTI-TUMOR ACTIVITY
    MARTIN, DG
    BILES, C
    GERPHEIDE, SA
    HANKA, LJ
    KRUEGER, WC
    MCGOVREN, JP
    MIZSAK, SA
    NEIL, GL
    STEWART, JC
    VISSER, J
    JOURNAL OF ANTIBIOTICS, 1981, 34 (09) : 1119 - 1125
  • [37] FoRx-06-428 is a novel PARG inhibitor with potent anti-tumor efficacy in preclinical cancer models
    Querolle, Olivier
    Lucking, Ulrich
    Iacovino, Luca
    Freudenmann, Alena
    Rossetti, Giacomo
    Gysin, Marina
    Bologna, Serena
    Dionellis, Vasilis
    Malattia, Marta
    Potenza, Alessandro
    Bocquet, Nicolas
    Konstantinova, Irena
    Goutopoulos, Andreas
    Sotiriou, Sotirios
    Halazonetis, Thanos
    Bashir, Tarig
    Zenke, Frank
    CANCER RESEARCH, 2024, 84 (06)
  • [38] Preclinical assessment of anti-tumor activity and immune response in syngeneic tumor models
    Franklin, M.
    Thayer, M.
    Draper, D.
    Saims, D.
    Wise, S.
    EUROPEAN JOURNAL OF CANCER, 2016, 69 : S97 - S97
  • [39] Discovery and characterization of a KRASG12C/D/V degrader with potent anti-tumor activity in KRASmut-driven preclinical models
    Li, Zhengqing
    Xu, Renqi
    Yang, Xiaofeng
    Zou, Zhengyao
    Kong, Xiaoqiang
    Chen, Haibo
    Sun, Yongqing
    Zhao, Ying
    Guo, Jing
    Yang, Cheng
    Han, Han
    Liu, Xiaoyun
    Lan, Hong
    Ding, Lieming
    Zhou, Quan
    Wu, Hao
    Wang, Jiabing
    CANCER RESEARCH, 2024, 84 (06)
  • [40] Preclinical Candidate SYN608-a Novel PARG Inhibitor with Excellent Anti-tumor Activity
    Shi, S.
    Tang, X.
    He, H.
    Ge, C.
    Cui, Y.
    Xie, Y.
    Kan, C.
    Liu, S.
    EUROPEAN JOURNAL OF CANCER, 2024, 211 : S134 - S134
12345