Preclinical characterization of ALG-031048, a novel STING agonist with potent anti-tumor activity in mice

被引:7
|
作者
Jekle, Andreas [1 ]
Thatikonda, Santosh [1 ]
Stevens, Sarah [1 ]
Williams, Caroline [1 ]
Kinkade, April [1 ]
Ren, Suping [1 ]
Jaisinghani, Ruchika [1 ]
Zhang, Qingling [1 ]
Misner, Dinah [1 ]
Stoycheva, Antitsa [1 ]
Deval, Jerome [1 ]
Mukherjee, Sucheta [1 ]
Gonzalvez, Francois [2 ]
Chanda, Sushmita [1 ]
Smith, David B. [1 ]
Symons, Julian A. [1 ]
Blatt, Lawrence M. [1 ]
Beigelman, Leonid [1 ]
机构
[1] Aligos Therapeut, San Francisco, CA USA
[2] Aligos Belgium, Leuven, Belgium
关键词
D O I
10.1158/1538-7445.AM2020-4520
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4520
引用
收藏
页数:2
相关论文
共 50 条
  • [11] A novel docetaxel derivative exhibiting potent anti-tumor activity and high safety in preclinical animal models
    Wang, Yao
    Wang, Penghui
    Zhou, Linzhu
    Su, Yue
    Zhou, Yongfeng
    Zhu, Xinyuan
    Huang, Wei
    Yan, Deyue
    BIOMATERIALS SCIENCE, 2022, 10 (17) : 4876 - 4888
  • [12] Vorolanib, a novel tyrosine receptor kinase receptor inhibitor with potent preclinical anti-angiogenic and anti-tumor activity
    Liang, Chris
    Yuan, Xiaobin
    Shen, Zhilin
    Wang, Yang
    Ding, Lieming
    MOLECULAR THERAPY-ONCOLYTICS, 2022, 24 : 577 - 584
  • [13] Preclinical characterization of a novel STING agonist, MK-1454
    Cemerski, Saso
    Altman, Michael
    Bandi, Madhavi
    Chang, Wonsuk
    Chen, Yiping
    Cui, Long
    Cumming, Jared
    Dorosh, Lauren
    Flateland, Lauren
    Ma, Yanhong
    Javaid, Sarah
    Ho, Thu
    Kopinja, Johnny
    Laskey, Jason
    Minnihan, Ellen
    Price, Laura
    Mogg, Robin
    O'Donnell, Gregory
    Pan, Bo-Sheng
    Perera, Samanthi
    Piesvaux, Jennifer
    Presland, Jeremy
    Rakhilina, Larissa
    Schroeder, Gottfried
    Slavonic, Michael
    Smock, Steven
    Trotter, Benjamin Wesley
    Wyss, Daniel
    Zhao, Qing
    Zhao, Shuxia
    Sadekova, Svetlana
    Yu, Ying
    Khilnani, Anuradha
    Tse, Archie
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
  • [14] Preclinical pharmacology of ABT-518, a novel and potent inhibitor of gelatinase A and B with anti-tumor activity.
    Albert, DH
    Morgan, DW
    Magoc, T
    Tapang, P
    Kherzai, A
    Marcotte, P
    Elmore, I
    Glaser, K
    Pease, L
    Li, J
    Leal, J
    Michaelides, M
    Curtin, M
    Holms, J
    Wada, C
    Dai, Y
    Davidson, SK
    CLINICAL CANCER RESEARCH, 2000, 6 : 4525S - 4525S
  • [15] TETROCARCINS, NOVEL ANTI-TUMOR ANTIBIOTICS .2. ISOLATION, CHARACTERIZATION AND ANTI-TUMOR ACTIVITY
    TAMAOKI, T
    KASAI, M
    SHIRAHATA, K
    OHKUBO, S
    MORIMOTO, M
    MINEURA, K
    ISHII, S
    TOMITA, F
    JOURNAL OF ANTIBIOTICS, 1980, 33 (09): : 946 - 950
  • [16] Tumor cell-targeted STING-agonist antibody-drug conjugates achieve potent anti-tumor activity by delivering STING agonist specifically to tumor cells andFcγRI-expressing subset of myeloid cells
    Cetinbas, Naniye Malli
    Catcott, Kalli C.
    Monnell, Travis
    Soomer-James, Jahna
    Bentley, Keith
    Clardy, Susan
    Du, Bingfan
    Kelleher, Eoin
    Protopopova, Marina
    Stevenson, Cheri
    Thomas, Joshua D.
    Uttard, Alex
    Toader, Dorin
    Duvall, Jeremy
    Bukhalid, Raghida
    Damelin, Marc
    Lowinger, Timothy B.
    CANCER RESEARCH, 2022, 82 (12)
  • [17] PDL192, a novel, humanized antibody to TWEAK receptor, shows potent anti-tumor activity in preclinical models
    Culp, P.
    Choi, D.
    Yin, J.
    Tan, S.
    Chao, D.
    Su, M.
    Sho, M.
    Steinte, R.
    Hsi, E.
    Ramakrishnan, V.
    EJC SUPPLEMENTS, 2008, 6 (12): : 161 - 161
  • [18] True small molecule STING agonist generates systemic and potent anti-tumor immunity required for effective cancer immunotherapy
    Kulkarni, Meghana M.
    Dwight, Timothy
    Marino, Kristen
    Allen, Bryce K.
    Taimi, Mohammed
    Bastos, Cecilia
    Lai, Sujen
    Koh, Cheryl
    Samant, Ramya
    Tesar, Bethany
    Huang, Huang
    Chamberlain, Brian
    Rice, James M.
    Tan, Dazhi
    Lin, Zhixiong
    Shechter, Sharon
    Li, Stella
    Sparks, Sam
    Soutter, Holly
    Swann, Steven
    Sherman, Woody
    Winter, Christopher
    MOLECULAR CANCER THERAPEUTICS, 2019, 18 (12)
  • [19] Combination of STING agonist with anti-vascular RGD-(KLAKLAK)2 peptide as a novel anti-tumor therapy
    Czapla, Justyna
    Drzyzga, Alina
    Ciepla, Joanna
    Matuszczak, Sybilla
    Jarosz-Biej, Magdalena
    Pilny, Ewelina
    Cichon, Tomasz
    Smolarczyk, Ryszard
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2024, 73 (08)
  • [20] STING VAX - A novel tumor vaccine with cyclic dinucleotides - can induce potent anti-tumor responses in vivo.
    Dubensky, Thomas W.
    Leong, Meredith L.
    Kanne, David B.
    Lemmens, Edward E.
    Metchette, Ken
    Liu, Weiqun
    Fasso, Marcella
    Fu, Juan
    Woodward, Joshua J.
    Pardoll, Drew
    Portnoy, Daniel A.
    Kim, Young J.
    CANCER RESEARCH, 2013, 73 (08)